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Browsing by Author Hackett, William E

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  • OER000000807.pdf.jpg
  • Journal article

  • Measuring site-specific glycosylation similarity between influenza A virus variants with statistical certainty

    • Authors : Chang, Deborah; Hackett, William E; Zhong, Lei (2020)

  • Influenza A virus (IAV) mutates rapidly, resulting in antigenic drift and poor year-to-year vaccine effectiveness. One challenge in designing effective vaccines is that genetic mutations frequently cause amino acid variations in IAV envelope protein hemagglutinin (HA) that create new N-glycosylation sequons; resulting N-glycans cause antigenic shielding, allowing viral escape from adaptive immune responses. Vaccine candidate strain selection currently involves correlating antigenicity...