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Browsing by Author Halbi, Gal

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  • OER000002690-2.pdf.jpg
  • Journal article

  • Smart-design of universally decorated nano-particles for drug delivery applications driven by active transport

    • Authors : Halbi, Gal (2023)

  • Targeting the cell nucleus remains a challenge for drug delivery. Here we present a universal platform for smart design of nano-particles (NPs) decoration that allows recruitment of multiple dynein motors to drive their active motion towards the nucleus. The uniqueness of our approach is based on using: (i) a spacer polymer, commonly Biotin-Polyethylene-glycol-thiol (B-PEG-SH), whose grafting density and molecular weight can be tuned thereby allowing NP trans...