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Browsing by Author Tabar, Mehdi Sharifi

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  • OER000000872.pdf.jpg
  • Journal article

  • The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture

    • Authors : Low, Jason KK; Silva, Ana PG; Tabar, Mehdi Sharifi (2020)

  • The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to biochemical analysis. We present the first integrated analysis of the architecture of the native mammalian NuRD complex, combining quantitative mass spectrometry, covalent cross-linking, protein biochemistry and electron microscopy. NuRD is built around a 2:2:4 pseudo-symmetric deacetylase module comprising MTA, HDAC and RBBP subunits. This mod...