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Browsing by Author Takenaka, Yasuhiro

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  • OER000000731.pdf.jpg
  • Journal article

  • NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

    • Authors : Nakano, Takanari; Inoue, Ikuo; Takenaka, Yasuhiro (2020)

  • Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1) protein, which mediates intracellular cholesterol trafficking from the brush border membrane to the endoplasmic reticulum, where chylomicron assembly takes place in enterocytes or in the intestinal absorptive epithelial cells. Cholesterol is a minor lipid component of chylomicrons; however, whether or not a shortage of cholesterol attenuates chylomicron assembly is unknown. The aim of this study was to examine the ...