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Browsing by Author Yakovlieva, Liubov

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  • OER000000248.pdf.jpg
  • Journal article

  • Semi-processive hyperglycosylation of adhesin by bacterial protein N-glycosyltransferases

    • Authors : Yakovlieva, Liubov; Ramírez-Palacios, Carlos; Marrink, Siewert J. (2020)

  • Processivity is an important feature of enzyme families such as DNA polymerases, polysaccharide synthases and protein kinases, to ensure high fidelity in biopolymer synthesis and modification; reveal processive character in the family of cytoplasmic protein N-glycosyltransferases (NGTs). Through various activity assays, intact protein mass spectrometry and proteomics analysis, we established that NGTs from non-typeable Haemophilus influenzae and Actinobacillus pleuropneumoniae modify an&#...
  • OER000000249.pdf.jpg
  • Journal article

  • Structural basis for binding mechanism of human serum albumin complexed with cyclic peptide dalbavancin

    • Authors : Yakovlieva, Liubov; Ramírez-Palacios, Carlos; Marrink, Siewert J. (2020)

  • Cyclic peptides, with unique structural features, have emerged as new candidates for drug discovery; their association with human serum albumin (HSA; long blood half-life), is crucial to improve drug delivery and avoid renal clearance. Here, we present the crystal structure of HSA complexed with dalbavancin, a clinically used cyclic peptide. SAXS and ITC experiments showed that the HSA-dalbavancin complex exists in a monomeric state; dalbavancin is only ...