Ebooks (Sách điện tử)Authors : Yamada, Ken (2023)
Metabolic stabilization of therapeutic oligonucleotides requires both sugar and backbone modifications,
where phosphorothioate (PS) is the only backbone chemistry used in the clinic. Here, we describe the discovery,
synthesis, and characterization of a novel biologically compatible backbone, extended nucleic acid (exNA). Upon
exNA precursor scale up, exNA incorporation is fully compatible with common nucleic acid synthetic protocols.
The novel backbone is orth... 
