Digital resources - Ha Noi university of science and technology

Browsing by Author Middleton, A.J.

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:

Showing results 1 to 1 of 1

Journal article

Identification of ubiquitin variants that inhibit the E2 ubiquitin conjugating enzyme, Ube2k

Authors : Middleton, A.J. (2021)

Transfer of ubiquitin to substrate proteins regulates most processes in eukaryotic cells. E2 enzymes are a central component of the ubiquitin machinery, and generally determine the type of ubiquitin signal generated and thus the ultimate fate of substrate proteins. The E2, Ube2k, specifically builds degradative ubiquitin chains on diverse substrates. Here we have identified protein-based reagents, called ubiquitin variants (UbVs), that ...