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Browsing by Author Ryan, Veronica H

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Periodicals (Báo – Tạp chí)

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins

Authors : Perdikari, Theodora Myrto; Murthy, Anastasia C; Ryan, Veronica H (2020)

Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of viruses and may assemble within viral factories, dynamic compartments formed within the host cells. Here, we examine the possibility that the multivalent RNA-binding nucleocapsid protein (N) from the severe acute respiratory syndrome coronavirus (SARS-CoV-2) compacts RNA via protein-RNA liquid-liquid phase separation (LLPS) and that N interactions with host RNA-binding proteins are mediat...

Journal article

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration

Authors : Ryan, Veronica H; Perdikari, Theodora Myrto; Naik, Mandar T (2020)

mRNA transport in neurons is a ubiquitous process but has been often overlooked as a contributor to disease. Mutations of transport granule protein hnRNPA2 cause hereditary proteinopathy of neurons, myocytes, and bone. Here, we examine transport granule component specificity, assembly/disassembly, and the link to neurodegeneration. hnRNPA2 transport granule components hnRNPF and ch-TOG interact weakly with hnRNPA2 yet they each partition specifically into hnRNPA2 liqui...