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  • OER000000677.pdf.jpg
  • Journal article

  • Authors : Billesbølle, Christian B; Azumaya, Caleigh M; Kretsch, Rachael C (2020)

  • The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin negatively regulates iron absorption and recycling by inducing ferroportin internalization and degradation. Aberrant ferroportin activity can lead to diseases of iron overload, like hemochromatosis, or iron limitation anemias. Here, we determined cryogenic electron microscopy (cryo-EM) structures of ferroportin in lipid nanodiscs,&#...