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Browsing by Subject 3C SARS-CoV-2

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Journal article

Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-Like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system

Authors : Verissimo, Carolina De Marco (2023)

During the SARS-CoV-2 intracellular life-cycle, two large polyproteins, pp1a and pp1ab, are 29 produced. Processing of these by viral cysteine proteases, the papain-like protease (PLpro) and 30 the chymotrypsin-like 3C-like protease (3CL-pro) release non-structural proteins necessary for 31 the establishment of the viral replication and transcription complex (RTC), crucial for viral 32 replication. Hence, these proteases are considered prime targets against which anti-COVID-19&#...