Browsing by Subject A (cyclo-PGFVSA)

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  • OER000000876.pdf.jpg
  • Journal article


  • Authors : Fisher, Mark F; Zhang, Jingjing; Berkowitz, Oliver (2020)

  • Small, cyclic peptides are reported to have many bioactivities. In bacteria and fungi they can be made by non-ribosomal peptide synthetases, but in plants they are exclusively ribosomal. Cyclic peptides from the Annona genus possess cytotoxic and anti-inflammatory activities, but their biosynthesis is unknown. The medicinal soursop plant, Annona muricata, contains annomuricatins A (cyclo-PGFVSA) and B (cyclo-PNAWLGT). Here, using de novo transcriptomics and tandem mass...