Browsing by Subject Ab initio folding

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  • OER000000191.pdf.jpg
  • Periodicals (Báo – Tạp chí)


  • Authors : Wiese, Jonas Gregor (2020)

  • To explore opportunities to extend and diversify this scaffold by adding a short de novo helix on top of the barrel. Due to the size of the protein we developed a design pipeline based on computational ab initio folding that solves a less complex sub-problem focused around the helix and its vicinity and adapt it to the entire protein. We provide biochemical characterization and a high-resolution X-ray structure for one variant and...