Browsing by Subject IAPP

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  • OER000000885.pdf.jpg
  • Journal article


  • Authors : Röder, Christine; Kupreichyk, Tatsiana; Gremer, Lothar (2020)

  • A critical role of the hormone islet amyloid polypeptide (IAPP) is vividly discussed for Type 2 Diabetes (T2D), where amyloid deposits in pancreatic islets consisting of fibrillar IAPP have been associated with beta cell loss. Here, we applied cryo-electron microscopy to elucidate the structure of IAPP fibrils prepared at physiological pH and reconstructed densities of three dominant polymorphs. An atomic model of the main polymorph comprising residues 1...