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Browsing by Subject N-terminomics

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  • OER000002318.pdf.jpg
  • Journal Article

  • FAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen

    • Authors : Ziegler, Alexander R. (2023)

  • Proteases comprise approximately 3% of the human genome and catalyse the cleavage of pepKde bonds1. Proteolysis is essenKal for maintaining protein homeostasis, altering substrate structure, funcKon, and localisaKon2. Proteases contribute to vital cellular funcKons such as cell growth and repair3, immune signalling4, and wound healing5,6; dysregulated protease acKviKes underpin numerous pathological condiKons including cancer, inflammaKon neurodegeneraKon, and gastrointesKnal diseases7. Knowle...