Browsing by Subject N1-Methylpseudouridine

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  • OER000002694.pdf.jpg
  • Journal article

  • Authors : Monroe, Jeremy G. (2023)

  • rapid and accurate protein production. The inclusion of chemically modified bases into mRNAs has the potential to alter the strength and pattern of hydrogen bonding between mRNAs and aminoacyl-tRNAs to alter protein synthesis. We investigated how the N1-methylpseudouridine (m1Y) modification, commonly incorporated into therapeutic and vaccine mRNA sequences, influences the ability of codons to react with cognate and near-cognate tRNAs and release factors. We find ...