Browsing by Subject Na + /taurocholate (NTCP)

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  • OER000000265.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Authors : Ruggiero, Melissa J; Malhotra, Shipra (2020)

  • Conventionally, most amino acid substitutions at important protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of non-conserved positions for which various substitutions produced progressive functional changes; we consider these evolutionary “rheostats”. Here, we report a strong rheostat position in the integral membrane protein, Na+/taurocholate cotransporting polypeptide (NTCP), at the site of a pharmacologically-...