Journal ArticleAuthors : Jockmann, Emely (2023)
S-Adenosyl-L-methionine (SAM) is an ubiquitous cofactor.[1] In nature, only 5´-adenosine triphosphate
(ATP) is used more often as an enzyme substrate.[2] The chemical structure of SAM was determined in
1952 by Cantoni et. al. and can be divided into two main components: an amino acid part arising from Lmethionine,
and an adenosyl part derived from ATP. Both moieties are linked by the positively charged
sulfonium, activating the cofacto... 
