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Browsing by Subject P-Neurokinin

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  • OER000002944.pdf.jpg
  • Journal article

  • Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics

    • Authors : Harris, Julian A. (2023)

  • The neuropeptide Substance P (SP) is important in pain and inflammation. SP activates the neurokinin-1 receptor (NK1R) to signal via Gqand Gs proteins. Neurokinin A also activates NK1R, but leads to selective Gq signaling. How two stimuli yield distinct G-protein signaling at the same G-protein-coupled-receptor remains unclear. We determined cryo-EM structures of active NK1R bound to SP or the Gq-biased peptide SP6-11. Peptide interactions deep within NK1R&#x...