Journal articleAuthors : Terwilliger, Thomas C; Ludtke, Steven J; Read, Randy J (2020)
A density modification procedure for improving maps produced by single-particle electron cryo-microscopy is presented. The theoretical basis of the method is identical to that of maximum-likelihood density modification, previously used to improve maps from macromolecular X-ray crystallography. Two key differences from applications in crystallography are that the errors in Fourier coefficients are largely in the phases in crystallography but in both phases and amplitudes... 
