Browse

Author Profile

Browsing by Subject p97/VCP UBXD1

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 1 of 1
  • OER000002462.pdf.jpg
  • Journal Article

  • The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

    • Authors : Braxton, Julian R. (2023)

  • p97/VCP is an essential cytosolic AAA+ ATPase hexamer that extracts and unfolds substrate 17 polypeptides during protein homeostasis and degradation. Distinct sets of p97 adapters guide 18 cellular functions but their roles in direct control of the hexamer are unclear. The UBXD1 19 adapter localizes with p97 in critical mitochondria and lysosome clearance pathways and 20 contains multiple p97-interacting domains. We identify UBXD1 as a ...