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Showing results 1 to 9 of 9
  • OER000000284.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Air and surface measurements of SARS-CoV-2 inside a bus during normal operation

    • Authors : Di Carlo, Piero; Chiacchiaretta, Piero; Sinjari, Bruna (2020)

  • Transmission pathways of SARS-CoV-2 are through aerosol, droplet and touching infected material. Indoor locations are more likely environments for the diffusion of the virus contagion among people, but direct detection of SARS-CoV-2 in air or on surfaces is quite sparse, especially regarding public transport. In fact, an important demand is to know how and if it is safe to use them. To understand the possible spreading of COVID-19 inside a ...
  • OER000000215.pdf.jpg
  • Journal article

  • An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

    • Authors : Zaidman, Daniel; Gehrtz, Paul; Filep, Mihajlo (2020)

  • Present covalentizer, a computational pipeline for creating irreversible inhibitors based on complex structures of targets with known reversible binders. For each ligand, we create a custom-made focused library of covalent analogs. We use covalent docking, to dock these tailored covalent libraries and to find those that can bind covalently to a nearby cysteine while keeping some of the main interactions of the original molecule. We found ~11,000 cysteine...
  • OER000000392.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Closing coronavirus spike glycoproteins by structure-guided design

    • Authors : McCallum, Matthew; Walls, Alexandra C; Corti, Davide (2020)

  • The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and host membranes. Although SARS-CoV- 2 S is the main target of neutralizing antibodies and the focus&...
  • OER000002368.pdf.jpg
  • Journal Article

  • Decreased efficacy of a COVID-19 vaccine due to mutations present in early SARS-CoV-2 variants of concern

    • Authors : Weidenbacher, Payton A.-B.  (2023)

  • With the SARS-CoV-2 virus still circulating and evolving, there remains an outstanding question if variant-specific vaccines represent the optimal path forward, or if other strategies might be more efficacious towards providing broad protection against emerging variants. Here, we examine the efficacy of strain-specific variants of our previously reported, pan-sarbecovirus vaccine candidate, DCFHP-alum, a ferritin nanoparticle functionalized with an engineered form ...
  • OER000002790.pdf.jpg
  • Journal article

  • Effects of the human-mobility change during the COVID-19 pandemic on electricity demand

    • Authors : Kentaka, Aruga (2022)

  • This study investigated how the changes in the number of people’s visits to various locations during the COVID-19 pandemic influenced electricity demand. Using the autoregressive distributed lag (ARDL) model, the study reveals that while an increase in visits to groceries, pharmacies stores, and transit stations increased electricity demand, an increase in the hours people spent at home had a negative impact on the demand during the pe...
  • OER000000134.pdf.jpg
  • Professional Practice Paper

  • Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

    • Authors : Frigerio, Roberto (2020)

  • Since the outbreak of COVID-19 crisis, the handling of biological samples from confirmed or suspected SARS-CoV-2 positive individuals demanded the use of inactivation protocols to ensure laboratory operators safety. While not standardized, these practices can be roughly divided in two categories, namely heat inactivation and solvent-detergent treatments. As such, these routine procedures should also apply to samples intended for Extracellular Vesicles (EVs) analysis. Assess...
  • OER000000741.pdf.jpg
  • Journal article

  • In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19

    • Authors : Orsburn, Benjamin C; Jenkins, Conor; Miller, Sierra M (2020)

  • We describe a method for rapid in silico selection of diagnostic peptides from newly described viral pathogens and applied this approach to SARS-CoV-2/COVID-19. This approach is multi-tiered, beginning with compiling the theoretical protein sequences from genomic derived data. In the case of SARS-CoV-2 we begin with 496 peptides that would be produced by proteolytic digestion of the viral proteins. To eliminate peptides that would cause cross-reactivity ...
  • OER000000775.pdf.jpg
  • Journal article

  • Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

    • Authors : Vankadari, Naveen (2020)

  • The SARS-CoV-2 pandemic is an urgent global public health emergency and warrants investigating molecular and structural studies addressing the dynamics of viral proteins involved in host cell adhesion. The recent comparative genomic studies highlight the insertion of Furin protease site in the SARS-CoV-2 spike glycoprotein alerting possible modification in the viral spike protein and its eventual entry to host cell and presence of Furin site implicated to...
  • OER000000166.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

    • Authors : Eberle, Raphael J. (2020)

  • The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide resulting in a pandemic of unprecedented magnitude. To date, no clinically safe drug or vaccine is available and the development of molecules to combat SARS-CoV-2 infections is imminent. A well-known strategy to identify molecules with inhibitory potential against SARS-CoV-2 proteins is the repurposing of clinically developed drugs, e.g., anti-parasitic drugs. The results described in this study dem...