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Browsing by Subject N-linked glycosylation

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  • OER000000830.pdf.jpg
  • Journal article

  • Identification of novel glycosylation events on human serum-derived Factor IX

    • Authors : Pegg, Cassandra L; Zacchi, Lucia F; Recinos, Dinora Roche (2020)

  • Human Factor IX is a highly post-translationally modified protein that is an important clotting factor in the blood coagulation cascade. Functional deficiencies in Factor IX result in the bleeding disorder haemophilia B, which is treated with plasma-derived or recombinant Factor IX concentrates. Here, we investigated the post-translational modifications of human serum-derived Factor IX and report previously undescribed O-linked monosaccharide compositions at serine 141 and&...