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Browsing by Subject S-adenosylmethionine

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Showing results 1 to 2 of 2
  • OER000000692.pdf.jpg
  • Journal article

  • Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program

    • Authors : Walvekar, Adhish S; Kadamur, Ganesh; Sreedharan, Sreesa (2020)

  • Methionine, through S-adenosylmethionine, activates multifaceted growth programs where ribosome biogenesis, carbon metabolism, amino acid and nucleotide biosynthesis are induced. This growth program requires activity of the Gcn4 transcription factor (called ATF4 in mammals), which enables metabolic precursor supply essential for anabolism. Here, we discover how the Gcn4 protein is induced by methionine, despite conditions of high translation and anabolism. This induction mechanism&#x...
  • OER000000713.pdf.jpg
  • Journal article

  • The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine

    • Authors : Lemus, Monica Rosas; Minasov, George; Shuvalova, Ludmilla (-)

  • SARS-CoV-2 is a member of the coronaviridae family and is the etiological agent of the respiratory Coronavirus Disease 2019. The virus has spread rapidly around the world resulting in over two million cases and nearly 150,000 deaths as of April 17, 2020. Since no treatments or vaccines are available to treat COVID-19 and SARS-CoV-2, respiratory complications derived from the infections have overwhelmed healthcare systems around the world. This virus...