Browsing by Subject S-adenosylmethionine

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  • OER000000692.pdf.jpg
  • Journal article


  • Authors : Walvekar, Adhish S; Kadamur, Ganesh; Sreedharan, Sreesa (2020)

  • Methionine, through S-adenosylmethionine, activates multifaceted growth programs where ribosome biogenesis, carbon metabolism, amino acid and nucleotide biosynthesis are induced. This growth program requires activity of the Gcn4 transcription factor (called ATF4 in mammals), which enables metabolic precursor supply essential for anabolism. Here, we discover how the Gcn4 protein is induced by methionine, despite conditions of high translation and anabolism. This induction mechanism&#x...

  • OER000000713.pdf.jpg
  • Journal article


  • Authors : Lemus, Monica Rosas; Minasov, George; Shuvalova, Ludmilla (-)

  • SARS-CoV-2 is a member of the coronaviridae family and is the etiological agent of the respiratory Coronavirus Disease 2019. The virus has spread rapidly around the world resulting in over two million cases and nearly 150,000 deaths as of April 17, 2020. Since no treatments or vaccines are available to treat COVID-19 and SARS-CoV-2, respiratory complications derived from the infections have overwhelmed healthcare systems around the world. This virus...