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Browsing by Subject Spike glycoprotein

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Showing results 2 to 3 of 3
  • OER000000775.pdf.jpg
  • Journal article

  • Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

    • Authors : Vankadari, Naveen (2020)

  • The SARS-CoV-2 pandemic is an urgent global public health emergency and warrants investigating molecular and structural studies addressing the dynamics of viral proteins involved in host cell adhesion. The recent comparative genomic studies highlight the insertion of Furin protease site in the SARS-CoV-2 spike glycoprotein alerting possible modification in the viral spike protein and its eventual entry to host cell and presence of Furin site implicated to...
  • OER000000864.pdf.jpg
  • Journal article

  • Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein

    • Authors : Walls, Alexandra C; Park, Young-Jun; Tortorici, M. Alejandra (2020)

  • The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main target of the humoral immune response. We show here that SARS-CoV-2 S mediates entry in VeroE6 cells and in BHK cells transiently transfected with human ACE2, establishing ACE2 ...