Journal articleAuthors : Müller, Henrik (2021)
αB-crystallin (ABC) is a human small heat shock protein that is strongly linked to Alzheimer’s
disease (AD). In vitro, it can inhibit the aggregation and amyloid formation of a range of proteins
including Aβ(1-40), a primary component of AD amyloid plaques. Despite the strong links, the
mechanism by which ABC inhibits amyloid formation has remained elusive, in part due to the
notorious irreproducibility of aggregation assays involving&...