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  • OER000002620.pdf.jpg
  • Journal article

  • The most probable ancestral sequence reconstruction yields proteins without systematic bias in thermal stability or activity

    • Authors : Sennett, Michael A. (2023)

  • Ancestral sequence resurrection (ASR) is the inference of extinct biological sequences from extant sequences, the most popular of which are based on probabilistic models of evolution. ASR is becoming a popular method for studying the evolution of enzyme characteristics. The properties of ancestral enzymes are biochemically and biophysically characterized to gain some knowledge regarding the origin of some enzyme property. Current methodology relies on resurrection ...