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  • OER000002677.pdf.jpg
  • Journal article

  • Structural basis of ubiquitin-independent PP1 complex disassembly by p97

    • Authors : Boom, Johannes van den (2023)

  • The AAA+ ATPase p97 (also called VCP, or Cdc48 in yeast) unfolds proteins and disassembles protein complexes in a myriad of cellular processes, but how a substrate complex needs to be loaded onto p97 by a dedicated substrate adapter and then disassembled by p97 has not been structurally visualized so far. Here we present cryo-EM structures of p97 in the process of disassembling a protein phosphatase-1 (PP1) complex by &#...