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  • 912-773267v3.full.pdf.jpg
  • Journal article


  • Authors : Fellner, Matthias; Lentz, Christian S; Jamieson, Sam A (2020)

  • Staphylococcus aureus is a major cause of infection in the community and in hospitals. Serine hydrolases play key roles in bacterial homeostasis, in particular biofilms. Activity-based profiling has previously identified a family of serine hydrolases, designated fluorophosphonate-binding hydrolases (Fphs), which contribute to virulence of S. aureus in the biofilm niche. Here we report structures of the putative tributyrin esterase FphF, alone and covalently bound by&#x...