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Browsing by Subject Spike glycoprotein

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  • OER000000196.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate

    • Authors : Tiwari, Vaibhav (2020)

  • The COVID-19 pandemic caused by SARS-CoV-2 is in immediate need of an effective antidote. Although the Spike glycoprotein (SgP) of SARS-CoV-2 has been shown to bind to heparins, the structural features of this interaction, the role of a plausible heparan sulfate proteoglycan (HSPG) receptor, and the antagonism of this pathway through small molecules remain unaddressed. Using an in vitro cellular assay, we demonstrate HSPGs modified by the 3-O-sulfotransf...
  • OER000000775.pdf.jpg
  • Journal article

  • Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

    • Authors : Vankadari, Naveen (2020)

  • The SARS-CoV-2 pandemic is an urgent global public health emergency and warrants investigating molecular and structural studies addressing the dynamics of viral proteins involved in host cell adhesion. The recent comparative genomic studies highlight the insertion of Furin protease site in the SARS-CoV-2 spike glycoprotein alerting possible modification in the viral spike protein and its eventual entry to host cell and presence of Furin site implicated to...
  • OER000000864.pdf.jpg
  • Journal article

  • Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein

    • Authors : Walls, Alexandra C; Park, Young-Jun; Tortorici, M. Alejandra (2020)

  • The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main target of the humoral immune response. We show here that SARS-CoV-2 S mediates entry in VeroE6 cells and in BHK cells transiently transfected with human ACE2, establishing ACE2 ...