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Showing results 1 to 20 of 20223
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  • Ebooks (Sách điện tử)


  • Authors : Monteverde, Gay (-)

  • 1, 2, 3 Write! retains a basic structure, several exercises and tables, and some nicely written explanations from Writing for Success, but about 75% of the original 96,000-word text was cut. Then, information on mechanics, expanded writing process steps, example readings, and a glossary was added. Chapters were organized to reflect a 1, 2, 3-step process, moving from words to sentences to paragraphs to essays. 1, 2, 3, Write! is desi...

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  • Book


  • Authors : Thạc, Bình Cường (2023)

  • Cuốn sách trình bày chi tiết kiến thức về các kỹ năng mềm cần thiết trong học tập, làm việc và cuộc sống hằng ngày như kỹ năng giao tiếp, thuyết trình, làm việc nhóm, lập kế hoạch và quản lý thời gian, viết email, đọc sách, v.v..

  • OER000001643.pdf.jpg
  • Book


  • Authors : - (2019)

  • This book provides insights into models and theoretical backgrounds, important properties, characterizations and applications of 2D materials, including graphene, silicon nitride, aluminum nitride, ZnO thin film, phosphorene and molybdenum disulfide.

  • OER000002338.pdf.jpg
  • Journal Article


  • Authors : Buchanan, Jane L. (2023)

  • Tryptophan is an essential amino acid that is extensively characterized as a regulator of cellular function through its metabolism by indoleamine 2,3-deoxygenase (IDO) into the kynurenine pathway. However, despite decades of research on tryptophan metabolism, the metabolic regulatory roles of it and its metabolites are not well understood. To address this, we performed an activity metabolomics screen of tryptophan and most of its known metabolit...

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  • Journal article


  • Authors : Srinivas, Pooja  (2023)

  • Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S rRNA (m7G1405) methyltransferases effectively blocks the action of all 4,6-deoxystreptamine ring-containing aminoglycosides, including the latest generation of drugs. To define the molecular basis of 30S subunit recognition ...

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  • Ebooks (Sách điện tử)


  • Authors : Lenssen, Philipp (2006)

  • This book, in a way, is born out of my daily weblog “Google Blogoscoped” (blog.outer-court.com) and those who read it. Since 2003 I’ve been writing there covering all things Google – not just the fun stuff, but news, discussion, interviews, tutorials, and everything beyond with a relation to search engines. Thanks to those reading along and providing pointers or feedback, I’ve been able to discover more interesting pag...

  • OER000002841.pdf.jpg
  • Journal article


  • Authors : Franziska, Holz (2021)

  • Carbon Capture and Storage (CCS) might be a central technology to reach the decarbonisation goals of the European energy system. However, CCS deployment faces multiple economic, technological, and infrastructure challenges. Related literature tends to only focus on certain aspects of the CCS technology or to be limited to a particular sector perspective. In contrast, this paper presents a holistic modelling framework to analyse the longterm ...

  • OER000002326.pdf.jpg
  • Journal Article


  • Authors : Daly, Leonard A. (2023)

  • Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalysed by Golgi-resident Tyrosyl Protein SulfoTransferases (TPSTs). Information on protein tyrosine sulfation is currently limited to ~50 human proteins with only a handful having verified sites of sulfation. The contribution of this chemical moiety for the regulation of biological processes, both inside and outside the cell, remains poorly defined, in large part due to analytica...

  • OER000002575.pdf.jpg
  • Journal article


  • Authors : Kim, C. (2023)

  • Orthosteric inhibition of kinases has been challenging due to the conserved active site architecture of kinases and emergence of resistance mutants. Simultaneous inhibition of distant orthosteric and allosteric sites, which we refer to as “double-drugging”, has recently been shown to be effective in overcoming drug resistance. However, detailed biophysical characterization of the cooperative nature between orthosteric and allosteric modulators has not be...

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  • Journal article


  • Authors : Raeburn, Candice B. (2021)

  • An extensive network of chaperones and other proteins maintain protein homeostasis and guard against inappropriate protein aggregation that is a hallmark of neurodegenerative diseases. Using a fluorescence resonance energy-based biosensor that simultaneously reports on intact cellular chaperone holdase activity and detrimental aggregation propensity, we investigated the buffering capacity of the systems managing protein homeostasis in the nucleus of the human cell l...

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  • Ebooks (Sách điện tử)


  • Authors : C.H., Swaroop (2020)

  • Python is probably one of the few programming languages which is both simple and powerful. This is good for beginners as well as for experts, and more importantly, is fun to program with. This book aims to help you learn this wonderful language and show how to get things done quickly and painlessly - in effect 'The Anti-venom to your programming problems'.

  • OER000002990.pdf.jpg
  • Journal article


  • Authors : Soubeyrand, Sébastien (2021)

  • Fibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling which has been proposed to contribute to atherosclerosis. Moreover, recent large scale genome wide association studies have linked common genetic variants within the FN1 gene to coronary artery disease (CAD) risk. Genome-wide Association Studies (GWAS) have identified hundreds of common single nucleotide polymorphisms (SNPs) that associate with cardiovascular disease (CA...

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  • Journal article


  • Authors : Nicholas, Nixon Opiyo (2019)

  • Sub-Saharan Africa continues to suffer energy poverty due to low grid expansion rates necessitated by low economic activities in those regions, sparse population distribution coupled with low household load demands, and insufficient power generation. On the other hand, small solar power microgeneration systems have emerged as potential alternatives to grid electrifications, enabling households to make modest investments into their power systems, and to&#x...

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  • Journal article


  • Authors : George, Amy L. (2023)

  • Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide interactions of small therapeutic molecules and their target and off-target proteins, complementing phenotypic-based drug screens. Detecting differences in thermal stability due to target engagement requires high quantitative accuracy and consistent detection. Isobaric tandem mass tags (TMT) are used to multiplex samples and increase quantification precision in TPP analysis by data-dependent acqui...

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  • Journal article


  • Authors : Sailer, Carolin (2023)

  • Eukaryotic ribosome biogenesis is facilitated and regulated by numerous ribosome biogenesis factors (RBFs). High-resolution cryo-EM maps have defined the molecular interactions of RBFs during maturation, but many transient and dynamic interactions, particularly during early assembly, remain uncharacterized. Using quantitative proteomics and crosslinking coupled to mass spectrometry (XL-MS) data from a extensive set of pre-ribosomal particles, we derived a comprehensive...

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  • Journal article


  • Authors : Paolo, Falbo (2021)

  • Due to recent technical progress, battery energy storages are becoming a viable option in the power sector. Their optimal operational management focuses on load shift and shaving of price spikes. However, this requires optimally responding to electricity demand, intermittent generation, and volatile electricity prices. More importantly, such optimization must take into account the so-called deep discharge costs, which have a significant impact on bat...

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  • Journal article


  • Authors : Melo, Eduardo P. (2023)

  • Protein disulfide isomerases (PDIs) are a family of molecular chaperones resident in the endoplasmic reticulum (ER) emerging as important factors in disease. In addition to an holdase function, some members catalyse disulfide bond formation and isomerization, a crucial step for native folding and prevention of aggregation of misfolded proteins. PDIs are characterized by a modular arrangement of thioredoxin-like domains, with the canonical, first identified PDIA1, ...

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  • Journal article


  • Authors : L, McAlary (2021)

  • Amyotrophic lateral sclerosis (ALS)-associated mutations in Cu/Zn superoxide dismutase (SOD1) reduce folding stability, resulting in misfolding, aggregation, and ultimately cellular toxicity. A great deal of effort has focused on preventing the misfolding and aggregation of SOD1 as a potential therapy for ALS, however, the results have been mixed. Here, we utilise a small-molecule polytherapy of CuATSM and ebselen to mimic the metal delivery and disulfide bon...