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  • Ebooks (Sách điện tử)


  • Authors : Monteverde, Gay (-)

  • 1, 2, 3 Write! retains a basic structure, several exercises and tables, and some nicely written explanations from Writing for Success, but about 75% of the original 96,000-word text was cut. Then, information on mechanics, expanded writing process steps, example readings, and a glossary was added. Chapters were organized to reflect a 1, 2, 3-step process, moving from words to sentences to paragraphs to essays. 1, 2, 3, Write! is desi...

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  • Book


  • Authors : Thạc, Bình Cường (2023)

  • Cuốn sách trình bày chi tiết kiến thức về các kỹ năng mềm cần thiết trong học tập, làm việc và cuộc sống hằng ngày như kỹ năng giao tiếp, thuyết trình, làm việc nhóm, lập kế hoạch và quản lý thời gian, viết email, đọc sách, v.v..

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  • Book


  • Authors : - (2019)

  • This book provides insights into models and theoretical backgrounds, important properties, characterizations and applications of 2D materials, including graphene, silicon nitride, aluminum nitride, ZnO thin film, phosphorene and molybdenum disulfide.

  • OER000002338.pdf.jpg
  • Journal Article


  • Authors : Buchanan, Jane L. (2023)

  • Tryptophan is an essential amino acid that is extensively characterized as a regulator of cellular function through its metabolism by indoleamine 2,3-deoxygenase (IDO) into the kynurenine pathway. However, despite decades of research on tryptophan metabolism, the metabolic regulatory roles of it and its metabolites are not well understood. To address this, we performed an activity metabolomics screen of tryptophan and most of its known metabolit...

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  • Journal article


  • Authors : Srinivas, Pooja  (2023)

  • Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S rRNA (m7G1405) methyltransferases effectively blocks the action of all 4,6-deoxystreptamine ring-containing aminoglycosides, including the latest generation of drugs. To define the molecular basis of 30S subunit recognition ...

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  • Ebooks (Sách điện tử)


  • Authors : Antonio Hernández, Bejarano (2018)

  • Cuốn sách này sẽ giới thiệu các khái niệm chính cần thiết để viết trò chơi 3D bằng thư viện LWJGL 3. LWJGL là một thư viện Java cung cấp quyền truy cập vào các API gốc được sử dụng để phát triển các ứng dụng đồ họa (OpenGL), âm thanh (OpenAL) và điện toán song song (OpenCL). Thư viện này tận dụng hiệu suất cao của các ứng dụng OpenGL gốc khi sử dụng ngôn ngữ Java. Mục tiêu ban đầu ...

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  • Ebooks (Sách điện tử)


  • Authors : Lenssen, Philipp (2006)

  • This book, in a way, is born out of my daily weblog “Google Blogoscoped” (blog.outer-court.com) and those who read it. Since 2003 I’ve been writing there covering all things Google – not just the fun stuff, but news, discussion, interviews, tutorials, and everything beyond with a relation to search engines. Thanks to those reading along and providing pointers or feedback, I’ve been able to discover more interesting pag...

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  • Journal article


  • Authors : Mullally, Grace; Aelst, Kara van; Naqvi, Mohsin M (2020)

  • A key aim in exploiting CRISPR-Cas is the engineering of gRNA to introduce additional functionalities, ranging from small nucleotide changes that increase efficiency of on-target binding to the inclusion of large functional RNA aptamers and ribonucleoproteins (RNPs. Interactions between gRNA and Cas9 are crucial for RNP complex assembly but several distinct regions of the gRNA are amenable to modification. Using a library of modified gRNAs, we used in&#x...

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  • Journal article


  • Authors : Franziska, Holz (2021)

  • Carbon Capture and Storage (CCS) might be a central technology to reach the decarbonisation goals of the European energy system. However, CCS deployment faces multiple economic, technological, and infrastructure challenges. Related literature tends to only focus on certain aspects of the CCS technology or to be limited to a particular sector perspective. In contrast, this paper presents a holistic modelling framework to analyse the longterm ...

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  • Journal article


  • Authors : Ghomi, Fatemeh Ashari; Kittilä, Tiia; Welner, Ditte Hededam (2020)

  • UDP-dependent glycosyltransferases (UGTs) are enzymes that glycosylate a wide variety of natural products, thereby modifying their physico-chemical properties, i.e. solubility, stability, reactivity, and function. To successfully leverage the UGTs in biocatalytic processes, we need to be able to screen and characterise them in vitro, which requires efficient heterologous expression in amenable hosts, preferably Escherichia coli. However, many UGTs are insoluble when expressed in...

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  • Journal Article


  • Authors : Daly, Leonard A. (2023)

  • Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalysed by Golgi-resident Tyrosyl Protein SulfoTransferases (TPSTs). Information on protein tyrosine sulfation is currently limited to ~50 human proteins with only a handful having verified sites of sulfation. The contribution of this chemical moiety for the regulation of biological processes, both inside and outside the cell, remains poorly defined, in large part due to analytica...

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  • Journal article


  • Authors : Lorton, Benjamin M; Harijan, Rajesh K; Burgos, Emmanuel S (2020)

  • Using highly accurate quantitative binding analysis combined with high-resolution crystal structures of WDR5 in complex with unmodified (me0) and me1/me2s L-Arginine amino acids and in complex with H3R2me1 peptide, we provide a rigorous biochemical study of this important biological interaction. Despite modest structural differences at the binding interface, our study supports an interaction model regulated by a binary arginine methylation switch: H3R2me2a prevents int...

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  • Journal article


  • Authors : Kim, C. (2023)

  • Orthosteric inhibition of kinases has been challenging due to the conserved active site architecture of kinases and emergence of resistance mutants. Simultaneous inhibition of distant orthosteric and allosteric sites, which we refer to as “double-drugging”, has recently been shown to be effective in overcoming drug resistance. However, detailed biophysical characterization of the cooperative nature between orthosteric and allosteric modulators has not be...

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  • Journal article


  • Authors : Raeburn, Candice B. (2021)

  • An extensive network of chaperones and other proteins maintain protein homeostasis and guard against inappropriate protein aggregation that is a hallmark of neurodegenerative diseases. Using a fluorescence resonance energy-based biosensor that simultaneously reports on intact cellular chaperone holdase activity and detrimental aggregation propensity, we investigated the buffering capacity of the systems managing protein homeostasis in the nucleus of the human cell l...

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  • Ebooks (Sách điện tử)


  • Authors : C.H., Swaroop (2020)

  • Python is probably one of the few programming languages which is both simple and powerful. This is good for beginners as well as for experts, and more importantly, is fun to program with. This book aims to help you learn this wonderful language and show how to get things done quickly and painlessly - in effect 'The Anti-venom to your programming problems'.

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  • Ebooks (Sách điện tử)


  • Authors : Richard, Bondi (2019)

  • Trong một tổ chức SRE, các nhóm thường phát triển các công cụ và quy trình tự động hóa rất khác nhau để hoàn thành các nhiệm vụ tương tự. Một số điều này có thể được giải thích bằng phần mềm mà chúng hỗ trợ: các hệ thống khác nhau yêu cầu các giải pháp có độ tin cậy khác nhau. Nhưng nhiều nhiệm vụ SRE về cơ bản là giống nhau trên tất cả các phần mềm: biên dịch, xây dựng, triể...

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  • Periodicals (Báo – Tạp chí)


  • Authors : Strzelecka, Dominika; Smietanski, Miroslaw (2020)

  • Chemical modifications enable preparation of mRNAs with augmented stability and translational activity. In this study, we explored how chemical modifications of 5’,3’-phosphodiester bonds in the mRNA body and polyA tail influence the biological properties of eukaryotic mRNA. To obtain modified and unmodified in vitro transcribed mRNAs, we used ATP and ATP analogues modified at the α-phosphate (containing either O-to-S or O-to-BH3 substitutions) and three different ...