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Showing results 10 to 29 of 20710
  • OER000002841.pdf.jpg
  • Journal article


  • Authors : Franziska, Holz (2021)

  • Carbon Capture and Storage (CCS) might be a central technology to reach the decarbonisation goals of the European energy system. However, CCS deployment faces multiple economic, technological, and infrastructure challenges. Related literature tends to only focus on certain aspects of the CCS technology or to be limited to a particular sector perspective. In contrast, this paper presents a holistic modelling framework to analyse the longterm ...

  • OER000002326.pdf.jpg
  • Journal Article


  • Authors : Daly, Leonard A. (2023)

  • Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalysed by Golgi-resident Tyrosyl Protein SulfoTransferases (TPSTs). Information on protein tyrosine sulfation is currently limited to ~50 human proteins with only a handful having verified sites of sulfation. The contribution of this chemical moiety for the regulation of biological processes, both inside and outside the cell, remains poorly defined, in large part due to analytica...

  • OER000002575.pdf.jpg
  • Journal article


  • Authors : Kim, C. (2023)

  • Orthosteric inhibition of kinases has been challenging due to the conserved active site architecture of kinases and emergence of resistance mutants. Simultaneous inhibition of distant orthosteric and allosteric sites, which we refer to as “double-drugging”, has recently been shown to be effective in overcoming drug resistance. However, detailed biophysical characterization of the cooperative nature between orthosteric and allosteric modulators has not be...

  • OER000002975.pdf.jpg
  • Journal article


  • Authors : Raeburn, Candice B. (2021)

  • An extensive network of chaperones and other proteins maintain protein homeostasis and guard against inappropriate protein aggregation that is a hallmark of neurodegenerative diseases. Using a fluorescence resonance energy-based biosensor that simultaneously reports on intact cellular chaperone holdase activity and detrimental aggregation propensity, we investigated the buffering capacity of the systems managing protein homeostasis in the nucleus of the human cell l...

  • OER000002116.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : C.H., Swaroop (2020)

  • Python is probably one of the few programming languages which is both simple and powerful. This is good for beginners as well as for experts, and more importantly, is fun to program with. This book aims to help you learn this wonderful language and show how to get things done quickly and painlessly - in effect 'The Anti-venom to your programming problems'.

  • OER000000266.pdf.jpg
  • Periodicals (Báo – Tạp chí)


  • Authors : Strzelecka, Dominika; Smietanski, Miroslaw (2020)

  • Chemical modifications enable preparation of mRNAs with augmented stability and translational activity. In this study, we explored how chemical modifications of 5’,3’-phosphodiester bonds in the mRNA body and polyA tail influence the biological properties of eukaryotic mRNA. To obtain modified and unmodified in vitro transcribed mRNAs, we used ATP and ATP analogues modified at the α-phosphate (containing either O-to-S or O-to-BH3 substitutions) and three different ...

  • OER000000265.pdf.jpg
  • Periodicals (Báo – Tạp chí)


  • Authors : Ruggiero, Melissa J; Malhotra, Shipra (2020)

  • Conventionally, most amino acid substitutions at important protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of non-conserved positions for which various substitutions produced progressive functional changes; we consider these evolutionary “rheostats”. Here, we report a strong rheostat position in the integral membrane protein, Na+/taurocholate cotransporting polypeptide (NTCP), at the site of a pharmacologically-...

  • OER000002990.pdf.jpg
  • Journal article


  • Authors : Soubeyrand, Sébastien (2021)

  • Fibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling which has been proposed to contribute to atherosclerosis. Moreover, recent large scale genome wide association studies have linked common genetic variants within the FN1 gene to coronary artery disease (CAD) risk. Genome-wide Association Studies (GWAS) have identified hundreds of common single nucleotide polymorphisms (SNPs) that associate with cardiovascular disease (CA...

  • OER000002831.pdf.jpg
  • Journal article


  • Authors : Nicholas, Nixon Opiyo (2019)

  • Sub-Saharan Africa continues to suffer energy poverty due to low grid expansion rates necessitated by low economic activities in those regions, sparse population distribution coupled with low household load demands, and insufficient power generation. On the other hand, small solar power microgeneration systems have emerged as potential alternatives to grid electrifications, enabling households to make modest investments into their power systems, and to&#x...

  • OER000002629.pdf.jpg
  • Journal article


  • Authors : George, Amy L. (2023)

  • Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide interactions of small therapeutic molecules and their target and off-target proteins, complementing phenotypic-based drug screens. Detecting differences in thermal stability due to target engagement requires high quantitative accuracy and consistent detection. Isobaric tandem mass tags (TMT) are used to multiplex samples and increase quantification precision in TPP analysis by data-dependent acqui...

  • OER000000412.pdf.jpg
  • Journal article


  • Authors : Jong, Luitzen de; Roseboom, Winfried; Kramer, Gertjan (2020)

  • In vivo chemical cross-linking combined with LCMSMS of digested extracts (in vivo CX-MS) can reveal stable and dynamic protein-protein interactions at a proteome wide-scale and at the peptide level. In vivo CX-MS requires a membrane permeable and cleavable cross-linker that enables isolation of target peptides and a fast and sensitive search engine to identify the linked peptides.

  • OER000002951.pdf.jpg
  • Journal article


  • Authors : Sailer, Carolin (2023)

  • Eukaryotic ribosome biogenesis is facilitated and regulated by numerous ribosome biogenesis factors (RBFs). High-resolution cryo-EM maps have defined the molecular interactions of RBFs during maturation, but many transient and dynamic interactions, particularly during early assembly, remain uncharacterized. Using quantitative proteomics and crosslinking coupled to mass spectrometry (XL-MS) data from a extensive set of pre-ribosomal particles, we derived a comprehensive...

  • OER000002840.pdf.jpg
  • Journal article


  • Authors : Paolo, Falbo (2021)

  • Due to recent technical progress, battery energy storages are becoming a viable option in the power sector. Their optimal operational management focuses on load shift and shaving of price spikes. However, this requires optimally responding to electricity demand, intermittent generation, and volatile electricity prices. More importantly, such optimization must take into account the so-called deep discharge costs, which have a significant impact on bat...

  • OER000002618.pdf.jpg
  • Journal article


  • Authors : Melo, Eduardo P. (2023)

  • Protein disulfide isomerases (PDIs) are a family of molecular chaperones resident in the endoplasmic reticulum (ER) emerging as important factors in disease. In addition to an holdase function, some members catalyse disulfide bond formation and isomerization, a crucial step for native folding and prevention of aggregation of misfolded proteins. PDIs are characterized by a modular arrangement of thioredoxin-like domains, with the canonical, first identified PDIA1, ...

  • OER000003045.pdf.jpg
  • Journal article


  • Authors : L, McAlary (2021)

  • Amyotrophic lateral sclerosis (ALS)-associated mutations in Cu/Zn superoxide dismutase (SOD1) reduce folding stability, resulting in misfolding, aggregation, and ultimately cellular toxicity. A great deal of effort has focused on preventing the misfolding and aggregation of SOD1 as a potential therapy for ALS, however, the results have been mixed. Here, we utilise a small-molecule polytherapy of CuATSM and ebselen to mimic the metal delivery and disulfide bon...

  • OER000002989.pdf.jpg
  • Journal article


  • Authors : Dongen, J.E. van (2021)

  • Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/associated nuclease (Cas) systems have repeatedly shown to have excellent performance in nucleotide sensing applications1– 8 5 9 . High specificity and selectivity of Cas effector proteins is determined by the CRISPR RNA’s (crRNA’s) interchangeable spacer sequence, as well as position and number of mismatches between target sequence and the crRNA sequence1 11 . Some diseases are characterized ...

  • OER000002245.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Delf, Liz (-)

  • Let’s begin by being real with each other: you’re probably in this class because you have to be. It fulfills a gen ed writing requirement you need to graduate, and you wouldn’t be here otherwise. And there is a good chance you’re not absolutely thrilled about it. That’s OK. I think I understand, but let me take a stab at some of your potential reactions to finding yourself in this writing class this term. Imagine t...

  • OER000002680.pdf.jpg
  • Journal article


  • Authors : Mylonas, Roman (2023)

  • Native molecular weight (MW) is one of the defining features of proteins. Denaturing gel electrophoresis (SDS-PAGE) is a very popular technique for separating proteins and determining their MW. Coupled with antibody-based detection, SDS-PAGE is widely applied for protein identification and quantitation. Yet, electrophoresis is poorly reproducible and the MWs obtained are often inaccurate. This hampers antibody validation and negatively impacts the reliability of western...

  • OER000003012.pdf.jpg
  • Journal article


  • Authors : Cheng, Jingdong (2021)

  • Assembly of the mitoribosome is largely enigmatic and involves numerous assembly factors. However, little is known about their function and the architectural transitions of the pre-ribosomal intermediates. Here, we solved cryo-EM structures of the human 39S large subunit pre-ribosomes, representing four distinct late state intermediates. Besides the MALSU1 complex, we identified several assembly factors, including the DDX28 helicase, MRM3, GTPBP10 and th...