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  • OER000003407.pdf.jpg
  • Ebooks (Sách điện tử)

  • Palo Alto Firewall Practical Guidance and Hands-On Labs

    • Authors : Hamid, Talebi; Xavier, Cawley (2023)

  • Cuốn sách này giải thích từng bước cách định cấu hình tường lửa Palo Alto trong mạng. Mỗi chương bắt đầu với mục tiêu học tập và chứa các giải thích từng bước cho người mới bắt đầu sử dụng GNS3 về cách xây dựng các kịch bản bảo mật khác nhau từ đầu.
  • OER000002708.pdf.jpg
  • Journal article

  • PAM binding ensures orientational integration during Cas4-Cas1-Cas2 mediated CRISPR adaptation

    • Authors : Dhingra, Yukti (2023)

  • Adaptation in CRISPR-Cas systems immunizes bacteria and archaea against mobile genetic 10 elements. In many DNA-targeting systems, the Cas4-Cas1-Cas2 complex is required for selection 11 and processing of DNA segments containing PAM sequences, prior to integration of these 12 “prespacer” substrates as spacers in the CRISPR array. We determined cryo-EM structures of the 13 Cas4-Cas1-Cas2 adaptation complex from the type I-C system that encodes st...
  • OER000000866.pdf.jpg
  • Journal article

  • PAM recognition by miniature CRISPR nucleases triggers programmable double-stranded DNA target cleavage

    • Authors : Karvelis, Tautvydas; Bigelyte, Greta; Young, Joshua K (2020)

  • In recent years, CRISPR-associated (Cas) nucleases have revolutionized the genome editing field. Being guided by an RNA to cleave double-stranded (ds) DNA targets near a short sequence termed a protospacer adjacent motif (PAM), Cas9 and Cas12 offer unprecedented flexibility, however, more compact versions would simplify delivery and extend application. Here, we present a collection of 10 exceptionally compact (422-603 amino acids) CRISPR-Cas nucleases that recognize&#x...
  • OER000002702.pdf.jpg
  • Journal article

  • Parallelization with Dual-Trap Single-Column Configuration Maximizes Throughput of Proteomic Analysis

    • Authors : Kreimer, Simion (2023)

  • Proteomic analysis on the scale that captures population and biological heterogeneity over hundreds to thousands of samples requires rapid mass spectrometry methods which maximize instrument utilization (IU) and proteome coverage while maintaining precise and reproducible quantification. To achieve this, a short liquid chromatography gradient paired to rapid mass spectrometry data acquisition can be used to reproducibly profile a moderate set of analytes. ...
  • OER000003017.pdf.jpg
  • Journal article

  • Parasitic wasps do not lack lipogenesis

    • Authors : Ruther, Joachim (2021)

  • Fatty acids are crucial primary metabolites for virtually any creature on earth. Therefore, most organisms do not rely exclusively on nutritional supply with fatty acids but have the ability to synthesize fatty acids and triacylglycerides de novo from carbohydrates, a process called lipogenesis. The ubiquity of lipogenesis has been questioned by a series of studies reporting that many parasitic wasps (parasitoids) do not accumulate lipid mass despite hav...
  • OER000008523.pdf.jpg
  • Ebooks (Sách điện tử)

  • Particle physics reference library. Volume 1, Theory and experiments

    • Authors : - (2020)

  • Tập 1 sách truy cập mở của loạt sách hướng dẫn này bao gồm các bài viết về mô hình chuẩn của vật lý hạt, cả từ góc độ lý thuyết và thực nghiệm. Nó cũng đề cập đến các chủ đề liên quan, chẳng hạn như vật lý ion nặng, vật lý neutrino và tìm kiếm vật lý mới ngoài mô hình chuẩn.
  • OER000001616.pdf.jpg
  • Book

  • Particle Physics Reference Library. Volume 1: Theory and Experiments

    • Authors : - (2020)

  • This first open access volume of the handbook series contains articles on the standard model of particle physics, both from the theoretical and experimental perspective. It also covers related topics, such as heavy-ion physics, neutrino physics and searches for new physics beyond the standard model.
  • OER000008522-1.pdf.jpg
  • Ebooks (Sách điện tử)

  • Particle physics reference library. Volume 2, Detectors for particles and radiation

    • Authors : - (2020)

  • Tập 2 sách hướng dẫn truy cập mở này đề cập đến các máy dò, cơ sở thí nghiệm lớn và xử lý dữ liệu, cho cả các thí nghiệm dựa trên máy gia tốc và không dựa trên máy gia tốc. Nó cũng đề cập đến các ứng dụng trong y học và khoa học sự sống. Một sáng kiến ​​chung của CERN-Springer, “Thư viện tham khảo Vật lý hạt” cung cấp các đóng góp đã được sửa đổi và cập nhật dựa trên...
  • OER000008521-1.pdf.jpg
  • Ebooks (Sách điện tử)

  • Particle physics reference library. Volume 3, Accelerators and colliders

    • Authors : - (2020)

  • Tập 3 truy cập mở của bộ sách hướng dẫn này đề cập đến vật lý, thiết kế, công nghệ và hoạt động của máy gia tốc, cũng như quang học chùm tia, động lực học và chẩn đoán. Một sáng kiến ​​chung của CERN-Springer, "Thư viện tham khảo vật lý hạt" cung cấp các đóng góp đã được sửa đổi và cập nhật dựa trên tài liệu đã xuất bản trước đó trong loạt Landolt-Boernstein nổi tiếng về vật lý&#x...
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  • Book

  • Particle Physics Reference Library. Volume 3: Accelerators and Colliders

    • Authors : - (2020)

  • This third open access volume of the handbook series deals with accelerator physics, design, technology and operations, as well as with beam optics, dynamics and diagnostics. A joint CERN-Springer initiative, the “Particle Physics Reference Library” provides revised and updated contributions based on previously published material in the well-known Landolt-Boernstein series on particle physics, accelerators and detectors (volumes 21A,B1,B2,C), which took stock of the field&#...
  • OER000000742.pdf.jpg
  • Journal article

  • Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex

    • Authors : Lobel, Joseph H; Gross, John D (2020)

  • Pat1 promotes the activation and assembly of multiple proteins during mRNA decay. After deadenylation, the Pat1/Lsm1-7 complex binds to transcripts containing oligo(A) tails, which can be modified by the addition of several terminal uridine residues. Pat1 enhances Lsm1-7 binding to the 3’ end, but it is unknown how this interaction is influenced by nucleotide composition. Here we examine Pat1/Lsm1-7 binding to a series of oligoribonucleotides containing&...
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  • Ebooks (Sách điện tử)

  • Patent Law and Managing Investments in Technology

    • Authors : Schuster, Michael (-)

  • What are Patents, Trademarks, Servicemarks, and Copyrights Some people confuse patents, copyrights, and trademarks. Although there may be similarities among these kinds of intellectual property protection, they are different and serve different purposes. Policy Behind Patent Laws: Congress created the patent system under a constitutional mandate, stating that such a system can be enacted “To promote the Progress of Science and useful Arts.” This promotion of ...
  • OER000002468.pdf.jpg
  • Journal Article

  • Pathogenic bacteria experience pervasive RNA polymerase backtracking during infection

    • Authors : Browning, Kaitlyn R. (2023)

  • Pathogenic bacteria and their eukaryotic hosts are in a constant arms race. Hosts have numerous defense mechanisms at their disposal that not only challenge the bacterial invaders, but have the potential to disrupt molecular transactions along the bacterial chromosome. However, it is unclear how the host impacts association of proteins with the bacterial chromosome at the molecular level during infection. This is partially due to the lack of a ...
  • OER000005506.pdf.jpg
  • Ebooks (Sách điện tử)

  • Paths : why is life filled with so many detours?

    • Authors : András, Gulyás; Zalán, Heszberger; ózsef, Biró (2021)

  • This open access book explores the amazing similarity between paths taken by people and many other things in life, and its impact on the way we live, teach and learn. Offering insights into the new scientific field of paths as part of the science of networks, it entertainingly describes the universal nature of paths in large networked structures. It also shows the amazing similarity in the ways humans and other - even nonliving&#...
  • OER000000017.pdf.jpg
  • Journal article

  • Pathways for Germany's Low-Carbon Energy Transformation Towards 2050

    • Authors : Hans-Karl, Bartholdsen (2019)

  • Describes three possible pathways for the transformation of the German energy system until 2050. The scenarios take into account current climate politics on a global, European, and German level and also include different demand projections, technological trends and resource prices. The model includes the sectors power, heat, and transportation and works on a Federal State level. For the analysis, the linear cost-optimizing Global Energy System Model (GE...
  • OER000000960.pdf.jpg
  • Ebooks (Sách điện tử)

  • Pattern Development: Sheet Metal Level 1

    • Authors : Coey, Brian (2021)

  • Cover all three forms of layout as well as geometric construction. It introduces the learner to the techniques used in parallel line, radial line, and triangulation. With videos and animations, the learner has an opportunity to play, pause, and rewind as they practice these techniques; material required for a level 1 sheet metal apprentice (Line E).
  • OER000001663.pdf.jpg
  • Book

  • Pattern Recognition, Tracking and Vertex Reconstruction in Particle Detectors

    • Authors : Frühwirth, Rudolf; Strandlie, Are (2021)

  • This open access book is a comprehensive review of the methods and algorithms that are used in the reconstruction of events recorded by past, running and planned experiments at particle accelerators such as the LHC, SuperKEKB and FAIR. The main topics are pattern recognition for track and vertex finding, solving the equations of motion by analytical or numerical methods, treatment of material effects such as multiple Coulomb scattering and ener...