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Showing results 16412 to 16431 of 21309
  • OER000000643.pdf.jpg
  • Journal article


  • Authors : Moisio, Olli; Palani, Senthil; Virta, Jenni (2020)

  • Folate receptor β (FR-β) is one of the markers expressed on macrophages and a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate (68Ga-FOL). First, we determined the affinity of 68Ga-FOL using human FR-β expressing cells. Then, we studied atherosclerotic mice with 68Ga-FOL and 18F-FDG PET/CT. After sacrifice, the tissues excised were measured with a γ-counter for ex vivo bio...

  • OER000000878.pdf.jpg
  • Journal article


  • Authors : M, Moreno-Oñate; A.M, Herrero-Ruiz; Dominguez, García (2020)

  • Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility, as it participates in different DNA repair and damage tolerance pathways in which gap-filling DNA synthesis is required. In this work we show that human Polλ is conjugated with Small ...

  • OER000002705.pdf.jpg
  • Journal article


  • Authors : Skowronek, Patricia (2023)

  • Data-independent acquisition (DIA) methods have become increasingly attractive in mass spectrometry (MS)-based proteomics, because they enable high data completeness and a wide dynamic range. Recently, we combined DIA with parallel accumulation – serial fragmentation (dia-PASEF) on a Bruker trapped ion mobility separated (TIMS) quadrupole time-of-flight (TOF) mass spectrometer. This requires alignment of the ion mobility separation with the downstream mass selective quadrupole, ...

  • OER000004051.pdf.jpg
  • Journal article


  • Authors : Khaje, Niloofar Abolhasani; Sharp, Joshua S (2019)

  • Hydroxyl radical protein footprinting (HRPF) is a powerful technique for probing changes in protein topography, based on quantifying the amount of oxidation of different regions of a protein. While quantification of HRPF oxidation at the peptide level is relatively common, quantification at the residue level is challenging due to the influence of oxidation on MS/MS fragmentation and the large number of complex and only partially chromatographically resol...

  • OER000000897.pdf.jpg
  • Journal article


  • Authors : Thillaivillalan, Dhanaraman; Singh, Swati; Killoran, Ryan C (2020)

  • Activated RAS GTPases signal by directly binding effector proteins. Effectors have a folded RAS association (RA) domain that binds exclusively to GTP-loaded RAS, but the specificity of most RA domains for >150 RAS superfamily GTPases is unknown. Ten RAS-association domain family (RASSF) proteins comprise the largest group of effectors, proposed to couple RAS to the pro-apoptotic Hippo pathway. We show that RASSF1-6 complex ...

  • OER000003138.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Dan, Blum (2020)

  • Sử dụng hướng dẫn trong hướng dẫn hiện trường toàn diện này để nhận được sự hỗ trợ của các giám đốc điều hành cấp cao trong việc điều chỉnh kế hoạch an ninh mạng hợp lý cho doanh nghiệp của bạn. Bạn sẽ học cách cải thiện mối quan hệ làm việc với các bên liên quan trong các môi trường phát triển, CNTT và kinh doanh kỹ thuật số phức tạp. Bạn sẽ biết cách ưu tiên chương trình bảo mật...

  • OER000000405.pdf.jpg
  • Journal article


  • Authors : Bai, Nan; Kirubakaran, Palani; Karanicolas, John (2020)

  • Recent years have brought a flood of interest in developing compounds that selectively degrade protein targets in cells, as exemplified by PROTACs. Fully realizing the promise of PROTACs to transform chemical biology by delivering degraders of diverse and undruggable protein targets has been impeded, however, by the fact that designing a suitable chemical linker between the functional moieties requires extensive trial and error. Here, we describe a struc...

  • OER000000909.pdf.jpg
  • Journal article


  • Authors : Chen, Haoxuan; Li, Xinyue; Yao, Maosheng (2020)

  • Breathing air is a fundamental human need, yet its safety, when challenged by various harmful or lethal substances, is often not properly guarded. For example, air toxicity is currently monitored only for single or limited number of known toxicants, thus failing to fully warn against possible hazardous air. Here, we discovered that within minutes living rats emitted distinctive profiles of volatile organic compounds (VOCs) via breath when exposed to...

  • E00000000110.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Tạ, Ngọc Đôn (2012)

  • Kể từ năm 2008, chuyên đề rây phân tử và vật liệu hấp phụ đã được biên soạn và chính thức được đưa vào chương trình giảng dạy cho học viên cao học và nghiên cứu sinh các ngành hóa học, kỹ thuật hóa học và vật liệu hóa học của Trường Đại học Bách khoa Hà Nội. Để phục vụ cho công tác học tập và giảng dạy, tác giả biên soạn cuốn sách “Rây phân tử và vật liệu hấp phụ” này. N...

  • OER000002720.pdf.jpg
  • Journal article


  • Authors : Keymakh, Margaret (2023)

  • Homologous recombination (HR) is a double-strand break DNA repair pathway that preserves chromosome structure. To repair the damaged recipient DNA, HR requires an intact donor DNA sequence located elsewhere in the genome. After the double-strand break is repaired, DNA sequence information can be transferred between donor and recipient DNA molecules through different mechanisms, including DNA crossovers that form between homologous chromosomes. Regulating...

  • OER000000646.pdf.jpg
  • Journal article


  • Authors : Shah, Shanaya Shital; Hartono, Stella; Piazza, Aurèle (2020)

  • Displacement loops (D-loops) are intermediates formed during homologous recombination that play a pivotal role in the fidelity of repair. Rdh54 (a.k.a. Tid1), a Rad54 paralog in Saccharomyces cerevisiae, is well-known for its role with Dmc1 recombinase during meiotic recombination. Yet contrary to Dmc1, Rdh54 is also present in somatic cells where its function is less understood. While Rdh54 enhances the Rad51 DNA strand invasion activity in vitro, it&#x...

  • OER000000335.pdf.jpg
  • Book


  • Authors : Jong-Dae Park (2019)

  • Part I Te Paradox of Sub-Saharan Africa: Disillusionment and Dilemma, Assessing the Role of Foreign Aid, Donors and Recipients. Part II Rethinking the Root Causes of Africa’s Under-Development: Review of Conventional Explanations, Uncovering the Main Root Cause: The Mindset Factor. Part III Africa’s Forgotten Mission of Nation-Building: What are Missing, Finding the Missing Links, Reasons for Optimism and the Tasks at Hand. Part IV Understanding Korean Develo...

  • OER000003211.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Krasimir, Tsonev (2018)

  • Nội dung cuốn sách về các mẫu / kỹ thuật thiết kế phổ biến được sử dụng khi phát triển với React. Nó bao gồm các kỹ thuật về bố cục, luồng dữ liệu, quản lý phần phụ thuộc và nhiều nội dung hơn.

  • OER000002268.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Lynne, Patricia (-)

  • I’ve organized the book in four sections, designed to help you locate the strategies and techniques you need as you work on your assignments: • Successful College Reading provides a guide for reading actively, including strategies for choosing where and when to read, annotating texts, and identifying main points. This section focuses on non-fiction texts because these make up the majority of what you will read in college. &#x...

  • OER000002267.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Hallsby, Atilla (2020)

  • Reading Rhetorical Theory also provides a number of additional advantages over a conventional textbook. • There is no cost to either the instructor or the student. • It enables instructors to teach in a range of modalities, or to move between online and in-person administration as needed. • It is formatted for reading/watching/listening on mobile devices and computers. • The online format allows course content can be&#x...

  • OER000003087.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Curry, Edward (2020)

  • This open access book explores the dataspace paradigm as a best-effort approach to data management within data ecosystems. It establishes the theoretical foundations and principles of real-time linked dataspaces as a data platform for intelligent systems. The book introduces a set of specialized best-effort techniques and models to enable loose administrative proximity and semantic integration for managing and processing events and streams. The book is divided...

  • OER000001772.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : - (2020)

  • This book covers a wide range of topics related to recent advancements in metallurgical engineering and electrodeposition such as metallurgy forming, structure, microstructure properties, testing and characterizations, and electrodeposition techniques. It also highlights the progress of metallurgical engineering, the ferrous and non-ferrous materials industries, and the electrodeposition of nanomaterials and composites.

  • OER000001053.pdf.jpg
  • Book


  • Authors : Mitra, Pinaki (2018)

  • Introductory Chapter: Recent Advances in Cryptography and Network Security, Chapter 2: A New Approximation Method for Constant Weight Coding and Its Hardware Implementation. Chapter 3: Protocol for Multiple Black Hole Attack Avoidance in Mobile Ad Hoc Networks. Chapter 4: A Survey of Machine Learning Techniques for Behavioral-Based Biometric User Authentication.