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Showing results 16352 to 16371 of 21090
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  • Ebooks (Sách điện tử)


  • Authors : Neubauer, Matthias (2017)

  • This book is open access under a CC BY-NC 4.0 license. This volume presents several case studies highlighting the latest findings in Industry 4.0 projects utilizing S-BPM features. Their potential is explored in detail, while the limits of engineering a company from a communication-centred perspective are also discussed. After a general introduction and an overview of the book in chapter 1, chapter 2 starts by condensing the industrial challenges&#x...

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  • Journal article


  • Authors : Zacchi, Lucia F; Recinos, Dinora Roche; Otte, Ellen (2020)

  • Proteomic analysis of bioreactor supernatants can inform on cellular metabolic status, viability, and productivity, as well as product quality, which can in turn help optimize bioreactor operation. Incubating mammalian cells in bioreactors requires the addition of polymeric surfactants such as Pluronic F68, which reduce the sheer stress caused by agitation. However, these surfactants are incompatible with mass spectrometry proteomics and must be eliminated during sampl...

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  • Journal article


  • Authors : Bååth, Jenny Arnling (2023)

  • Interfacial enzyme reactions are common in nature and in industrial settings, including the enzymatic 13 deconstruction of poly(ethylene terephthalate) (PET) waste. Kinetic descriptions of PET hydrolases are 14 necessary for both comparative analyses, discussions of structure-function relations and rational 15 optimization of technical processes. We investigated whether the Sabatier principle could be used for 16 this purpose. Specifically, we compared the kinetics of two&#...

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  • Ebooks (Sách điện tử)


  • Authors : Gilchrist, Roberta (2022)

  • In this open access volume, Roberta Gilchrist critically evaluates the concept of sacred heritage. Drawing on global perspectives from heritage studies, archaeology, museology, anthropology and architectural history, she examines the multiple values of medieval Christian heritage. Gilchrist investigates monastic archaeology through the lens of the material study of religion and reveals the sensory experience of religion through case studies including Glastonbury Abbey and S...

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  • Book


  • Authors : Thomas Otto (2021)

  • This open access book offers a first introduction to safety at accelerator facilities. Presenting an overview of the safety-related aspects of the specific technologies employed in particle accelerators, it highlights the potential hazards at such facilities and current prevention and protection measures. It closes with a review of safety management and organization at accelerator facilities.

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  • Thesis


  • Authors : Đinh Xuân Thọ;  Advisor : Hà Quốc Trung (2012)

  • Giới thiệu dữ liệu phân tán và sao lưu dữ liệu phân tán. Mô hình hoạt động của hệ thống siêu thị, tổ chức dữ liệu và phương thức hoạt động của siêu thị. Các mô hình mới giải quyết nhược điểm của các mô hình hiện tại.

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  • Journal Article


  • Authors : Davies, Jonathan P. (2023)

  • Coronaviruses (CoV), including SARS-CoV-2, modulate host proteostasis through activation of stress-responsive signaling pathways such as the Unfolded Protein Response (UPR), which remedies misfolded protein accumulation by attenuating translation and increasing protein folding capacity. While CoV nonstructural proteins (nsps) are essential for infection, little is known about the role of nsps in modulating the UPR. We characterized the impact of SARS-CoV-2 ns...

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  • Periodicals (Báo – Tạp chí)


  • Authors : Perdikari, Theodora Myrto; Murthy, Anastasia C; Ryan, Veronica H (2020)

  • Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of viruses and may assemble within viral factories, dynamic compartments formed within the host cells. Here, we examine the possibility that the multivalent RNA-binding nucleocapsid protein (N) from the severe acute respiratory syndrome coronavirus (SARS-CoV-2) compacts RNA via protein-RNA liquid-liquid phase separation (LLPS) and that N interactions with host RNA-binding proteins are mediat...

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  • Journal Article


  • Authors : Chesney, Andrew D (2023)

  • Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s disease let to the idea that amyloidogenic segments in SARS-COV-2 proteins can induce aggregation of α-synuclein. Using molecular dynamic simulations, we show that the fragment FKNIDGYFKI of the spike protein, which is unique for SARS-COV-2, shifts preferentially the ensemble of α-synuclein&#x...

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  • Journal article


  • Authors : Weekley, Claire M. (2021)

  • Since SARS-CoV-2 emerged in 2019, genomic sequencing has identified mutations in the viral RNA including in the receptor-binding domain of the Spike protein. Structural characterisation of the Spike carrying point mutations aids in our understanding of how these mutations impact binding of the protein to its human receptor, ACE2, and to therapeutic antibodies. The Spike G485R mutation has been observed in multiple isolates of the virus and mutation ...

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  • Journal article


  • Authors : Oliveira, A. Sofia F. (2023)

  • The SARS-CoV-2 spike protein contains a fatty acid binding site, also found in some other coronaviruses (e.g. SARS-CoV), which binds linoleic acid and is functionally important. When occupied by linoleic acid, it reduces infectivity, by ‘locking’ the spike in a less infectious conformation. Here, we use dynamical-nonequilibrium molecular dynamics (D-NEMD) simulations to compare the response of spike variants to linoleic acid removal. These simulations show that&#x...

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  • Ebooks (Sách điện tử)


  • Authors : Nguyen, Tien M. (2021)

  • Note 520 This book provides a high-level overview of the current state of the art and future of satellite systems, satellite control systems, and satellite systems design. Chapters cover such topics as existing and future satellite systems, satellite communication subsystems, space control and Space Situation Awareness (SAA), machine learning methods with novel neural networks, data measurements in Global Navigation Satellite Systems, and much more.&...

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  • Journal article


  • Authors : Hobbs, Helen T. (2023)

  • Many tyrosine kinases cannot be expressed readily in E. coli, limiting facile production of these proteins for biochemical experiments. We used ancestral sequence reconstruction to generate a spleen tyrosine kinase (Syk) variant that can be expressed in bacteria and purified in soluble form, unlike the human members of this family (Syk and ZAP-70). The catalytic activity, substrate specificity, and regulation by phosphorylation of this Syk ...

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  • Book


  • Authors : Nghiêm Hùng (1997)

  • Cuốn sách cung cấp những thông tin tra cứu thông dụng về thép và gang. Bao gồm: Tổng quan về các tiêu chuẩn; thép xây dựng; thép kết cấu để chế tạo máy

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  • Book


  • Authors : Lê Quang Diễn (2021)

  • Khái quát công nghiệp giấy thế giới và Việt Nam, phân loại bột giấy và các phương pháp sản xuất, tính chất và các chỉ tiêu chất lượng của bột giấy; Nguyên liệu sản xuất bột giấy; chuẩn bị nguyên liệu, công nghệ nấu sunfit, kiềm hiện đại; Rửa, sàng chọn và làm sạch bột; Thu hồi hóa chất trong sản xuất bột hóa...