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Showing results 18709 to 18728 of 21501
  • OER000000691.pdf.jpg
  • Journal article


  • Authors : Rao, Maya V; Grasty, Kimberly C; Mehetre, Prajakta D (2020)

  • Ubiquitin signaling networks modulate almost all aspects of eukaryotic biology, and their outputs reflect the dynamic balance between ubiquitin attachment and removal. The latter process is catalyzed by deubiquitinating enzymes (DUBs), which must be carefully regulated to ensure that their activities are applied appropriately. Ataxin3 is a DUB that participates in quality-control pathways that support cellular health; however, the regulation of its activity has remaine...

  • OER000004052.pdf.jpg
  • Journal article


  • Authors : Branigan, Emma; Penedo, J. Carlos; Hay, Ronald T (2019)

  • Using single molecule Förster Resonance Energy Transfer (smFRET) to test this hypothesis and demonstrate that ubiquitin is transferred from the closed conformation during an E3 catalysed reaction. Using Ubc13 as an E2, we designed a FRET labelled E2~Ub conjugate, which distinguishes between closed and alternative conformations. Firstly, we defined the high FRET state as the closed conformation using a stable isopeptide linked E2~Ub conjugate, while the low&#x...

  • OER000002355.pdf.jpg
  • Journal Article


  • Authors :  Katzschmann, Anja (2023)

  • Affilin proteins (artificial binding proteins based on the ubiquitin scaffold) were generated using directed protein evolution to yield de‐novo variants that bind the extra‐domain B (EDB) of oncofetal fibronectin, an abundant tumor marker in fetal and neoplastic tissues. Structures of two EDB‐specific Affilin molecules reveal striking structural plasticity of the ubiquitin scaffold, characterized by β‐strand slippage, leading to diverse register shifts of ...

  • OER000002626.pdf.jpg
  • Journal article


  • Authors : Clifton, Ben E. (2023)

  • SAR11 bacteria are the most abundant members of the global ocean microbiome and have a broad impact on ocean ecosystems. To thrive in their competitive oligotrophic environments, these bacteria rely on solute-binding proteins (SBPs) that facilitate nutrient uptake through ABC transporters. Nonetheless, previous studies have been unable to access the molecular mechanisms and functions of these transporters because they rely heavily on homology-based p...

  • OER000002756.pdf.jpg
  • Journal article


  • Authors : Arruda, Hiam R. S. (2023)

  • The severe acute respiratory syndrome CoV-2 rapidly spread worldwide, causing a 43 pandemic. After a period of evolutionary stasis, a set of SARS-CoV-2 mutations has arisen in the 44 spike, the leading glycoprotein at the viral envelope and the primary antigenic candidate for 45 vaccines against the 2019 CoV disease (COVID-19). Here, we present comparative biochemical 46 data of the glycosylated full-length ancestral and D614G spike to...

  • OER000000843.pdf.jpg
  • Journal article


  • Authors : Figon, Florent; Munsch, Thibaut; Croix, Cécile (2020)

  • Ommochromes are widespread pigments that mediate multiple functions in invertebrates. The two main families of ommochromes are ommatins and ommins, which both originate from the kynurenine pathway but differ in their backbone, thereby in their coloration and function. Despite its broad significance, how the structural diversity of ommochromes arises in vivo has remained an open question since their first description. In this study, we combined organic synthes...

  • OER000002435.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Larson, Grant  (2023)

  • DosS is a heme-sensor histidine kinase that responds to redox-active stimuli in mycobacterial environments by triggering dormancy transformation. Sequence comparison of the catalytic ATP-binding (CA) domain of DosS to other well-studied histidine kinases suggests that it possesses a rather short ATP-lid. This feature has been thought to inhibit DosS kinase activity by blocking ATP binding in the absence of interdomain interactions with the dimerization and histidi...

  • OER000003189.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Tania, Rascia (2020)

  • Nội dung cuốn sách bao gồm bao gồm các chủ đề: Cấu trúc cây DOM và DOM; Cách truy cập, duyệt qua và sửa đổi các nút và thành phần trong DOM; Cách sửa đổi các thuộc tính, lớp và kiểu trong DOM; Sử dụng các sự kiện để tạo các trang web tương tác, năng động. Mỗi chương là khép kín và có thể được theo dõi độc lập với các chương khác. Tuy nhiên, nếu bạn chưa quen với khái niệm DOM...

  • OER000001335.pdf.jpg
  • Book


  • Authors : David Kember (2016)

  • This book is based upon three interrelated open naturalistic studies conducted to better characterise the motivational orientation of students in higher education. Open semi-structured individual interviews were conducted with undergraduates, students at community colleges and students in taught postgraduate courses in Hong Kong. The analysis used an exploratory grounded theory approach and resulted in a motivational orientation framework with six continua with positive and...

  • OER000002648.pdf.jpg
  • Journal article


  • Authors : Ooka, Hideshi (2023)

  • Design principles to improve enzymatic activity are essential to promote energy-material conversion using biological systems. For more than a century, the Michaelis-Menten equation has provided a fundamental framework of enzymatic activity. However, there is still no concrete guideline on how the parameters should be optimized to enhance enzymatic activity. Here, we demonstrate that tuning the Michaelis-Menten constant (𝐾𝑚) to the substrate concentration (𝑆) maximizes&#x...

  • OER000002430.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Schubert, Katharina (2023)

  • Nonstructural protein 1 (Nsp1) produced by coronaviruses shuts down host protein synthesis in infected cells. The C-terminal domain of SARS-CoV-2 Nsp1 was shown to bind to the small ribosomal subunit to inhibit translation, but it is not clear whether this mechanism is broadly used by coronaviruses, whether the N-terminal domain of Nsp1 binds the ribosome, or how Nsp1 specifically permits translation of viral mRNAs. Here, we investigat...

  • OER000001914.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Kwantlen Polytechnic University Learning Centres (2018)

  • University 101: Study Strategize Succeed helps students to create a foundation for post-secondary studies by learning how to learn. By taking the time to read this book and work through the exercises included, students are investing in the skills that will support them in all of their classes and future learning. Successful students share a set of skills and habits in common. The good news is that these skills are not a secret;&#...

  • OER000001994-1.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Moebs, William (2021)

  • University Physics is designed for the two- or threesemester calculus-based physics course. The text has been developed to meet the scope and sequence of most university physics courses and provides a foundation for a career in mathematics, science, or engineering. The book provides an important opportunity for students to learn the core concepts of physics and understand how those concepts apply to their lives and to the world around&#x...

  • OER000001995-1.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : Moebs, William (2021)

  • Our University Physics textbook adheres to the scope and sequence of most two- and threesemester physics courses nationwide. We have worked to make physics interesting and accessible to students while maintaining the mathematical rigor inherent in the subject. With this objective in mind, the content of this textbook has been developed and arranged to provide a logical progression from fundamental to more advanced concepts, building upon what ...

  • OER000001988-1.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : LING, SAMUEL J. (2021)

  • Our investigation of light revolves around two questions of fundamental importance: (1) What is the nature of light, and (2) how does light behave under various circumstances? Answers to these questions can be found in Maxwell’s equations (in Electromagnetic Waves), which predict the existence of electromagnetic waves and their behavior. Examples of light include radio and infrared waves, visible light, ultraviolet radiation, and X-rays. Interes...

  • OER000000687.pdf.jpg
  • Journal article


  • Authors : Thomas, Nathan E; Wildman, Katherine A. Henzler (2020)

  • TTransport stoichiometry provides insight into the mechanism and function of ion-coupled transporters, but measuring transport stoichiometry is time-consuming and technically difficult. With the increasing evidence that many ion-coupled transporters employ multiple transport stoichiometries under different conditions, improved methods to determine transport stoichiometry are required to accurately characterize transporter activity. Reversal potential was previously shown to be a reliable, general&#...