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  • Journal article

  • Dimerization mechanism and structural features of human LI-cadherin

    • Authors : Fleisher, Rachel C. (2021)

  • LI-cadherin is a member of the cadherin superfamily, which encompasses a group of Ca2+ dependent cell adhesion proteins. The expression of LI-cadherin is observed on various types of cells in the human body, such as normal small intestine and colon cells, and gastric cancer cells. Because its expression is not observed on normal gastric cells, LI-cadherin is a promising target for gastric cancer imaging. However, since...
  • Journal article

  • Mechanistic studies of non-canonical amino acid mutagenesis

    • Authors : Fleisher, Rachel C. (2021)

  • Over the past decade, harnessing the cellular protein synthesis machinery to incorporate non canonical amino acids (ncAAs) into tailor-made peptides has significantly advanced many aspects of molecular science. More recently, groundbreaking progress in our ability to engineer this machinery for improved ncAA incorporation has led to significant enhancements of this powerful tool for biology and chemistry. By revealing the molecular basis for t...