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  • Journal article

  • Nanopore dwell time analysis permits sequencing and conformational assignment of pseudouridine in SARS-CoV-2

    • Authors : Fleming, Aaron M. (2021)

  • Nanopore devices can directly sequence RNA, and the method has the potential to determine locations of epitranscriptomic modifications that have grown in significance because of their roles in cell regulation and stress response. Pseudouridine (Ψ), the most common modification in RNA, was sequenced with a nanopore system using a protein sensor with a helicase brake in synthetic RNAs with 100% modification at 18 known human pseudouridinylati...
  • Journal article

  • Considerations on activity determinants of fungal polyphenol oxidases based on mutational and structural studies

    • Authors : Nikolaivits, Efstratios (2021)

  • Polyphenol oxidases (PPOs) are an industrially relevant family of enzymes, being involved in the post-harvest browning of fruits and vegetables, as well as in human melanogenesis. Their involvement lies in their ability to oxidize phenolic or polyphenolic compounds, that subsequently form pigments. PPO family includes tyrosinases and catechol oxidases, which in spite of their high structural similarity, exhibit different catalytic activities. Long-standing research efforts&...