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  • Journal article

  • Antisense pairing and SNORD13 structure guide RNA cytidine acetylation

    • Authors : Gamage, Supuni Thalalla (2023)

  • N4-acetylcytidine (ac4C) is an RNA nucleobase found in all domains of life. Establishment of ac4C in helix 45 (h45) of human 18S ribosomal RNA (rRNA) requires the combined activity of the acetyltransferase NAT10 and the box C/D snoRNA SNORD13. However, the molecular mechanisms governing RNA-guided nucleobase acetylation in humans remain unexplored. Here we report two assays that enable the study of SNORD13-dependent RNA acetylation in human cells. F...
  • Journal article

  • Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

    • Authors : Yadav, Ruchi (2023)

  • SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 34 pandemic. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved 35 by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essential 36 yet incompletely understood. We studied Mpro-mediated processing of the nsp7-10/11 37 polyprotein, whose mature products are cofactors of the viral replicase, identifying the&#...