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  • Ebooks (Sách điện tử)

  • Molecular Marker Technology for Crop Improvement

    • Authors : - (2020)

  • This Special Issue collects 16 research studies, including the application of molecular markers in 11 crop species, from the generation of linkage maps and diversity studies to the application of marker-assisted selection and genomic prediction.
  • Ebooks (Sách điện tử)

  • Metabolites from Phototrophic Prokaryotes and Algae Volume 2

    • Authors : - (2020)

  • This book represents research papers based around metabolomics, to improve knowledge on the metabolome and metabolism in algae, with a focus on carbon and nitrogen resource allocation. It also describes many bioanalytical techniques and emphasizes their usefulness in microalgal biotechnology. Other aspects from an ecological, biotechnological and waste-water remediation perspective are also covered.
  • Ebooks (Sách điện tử)

  • Novel Enzyme and Whole-Cell Biocatalysts

    • Authors : - (2020)

  • In this book, we highlight these current advances in the field of biocatalysis, with special emphasis on novel enzymes and whole-cell biocatalysts for applications in several industrial biotechnological applications.
  • Ebooks (Sách điện tử)

  • Biomass Processing for Biofuels, Bioenergy and Chemicals

    • Authors : - (2020)

  • This book provides a comprehensive overview and in-depth technical research addressing recent progress in biomass conversion processes. It also covers studies on advanced techniques and methods for bioenergy and biofuel production.
  • Journal article

  • Pentapeptide repeat proteins QnrB1 and AlbG require ATP hydrolysis to rejuvenate poisoned gyrase complexes

    • Authors : Mazurek, Łukasz; Ghilarov, Dmitry; Michalczyk, Elizabeth (2020)

  • Activities of two such proteins, QnrB1 and AlbG in vitro. Each of them provided specific protection against its cognate toxin (fluoroquinolone or albicidin), which strictly required ATP hydrolysis by gyrase. Through a combination of fluorescence anisotropy, pull-downs and photocrosslinking we show that QnrB1 binds to the GyrB protein. We further probed the QnrB1 binding site using site-specific incorporation of a photoreactive amino acid and mapped strong and...
  • Periodicals (Báo – Tạp chí)

  • The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

    • Authors : Eberle, Raphael J. (2020)

  • The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide resulting in a pandemic of unprecedented magnitude. To date, no clinically safe drug or vaccine is available and the development of molecules to combat SARS-CoV-2 infections is imminent. A well-known strategy to identify molecules with inhibitory potential against SARS-CoV-2 proteins is the repurposing of clinically developed drugs, e.g., anti-parasitic drugs. The results described in this study dem...
  • Periodicals (Báo – Tạp chí)

  • Public LC-Orbitrap-MS/MS Spectral Library for Metabolite Identification

    • Authors : Phapale, Prasad (2020)

  • Liquid chromatography-mass spectrometry(LC-MS)-based untargeted metabolomics studies require high-quality pectral libraries for reliable metabolite identification. We have constructed EMBL-MCF, an open LC-MS/MS pectral library that currently contains over 1600 fragmentation spectra from 435 authentic standards of dogenous metabolites and lipids. The unique features of the library are presence of chromatographic profiles cquired with different LC-MS methods and coverage of different adduct...
  • Journal article

  • An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

    • Authors : Zaidman, Daniel; Gehrtz, Paul; Filep, Mihajlo (2020)

  • Present covalentizer, a computational pipeline for creating irreversible inhibitors based on complex structures of targets with known reversible binders. For each ligand, we create a custom-made focused library of covalent analogs. We use covalent docking, to dock these tailored covalent libraries and to find those that can bind covalently to a nearby cysteine while keeping some of the main interactions of the original molecule. We found ~11,000 cysteine...
  • Journal article

  • Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

    • Authors : Mahootchi, Elaheh; Raasakka, Arne; Luan, Weisha (2020)

  • the crystal structure of mouse CSAD and compared it to other PLP-dependent decarboxylases in order to identify determinants of substrate specificity and catalytic activity. Recognition of the substrate involves distinct side chains forming the substrate-binding cavity. In addition, the backbone conformation of a buried active-site loop appears to be a critical determinant for substrate side chain binding in PLPdependent decarboxylases. phe94 was predicted to affect...