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  • Ebooks (Sách điện tử)

  • Metabolites from Phototrophic Prokaryotes and Algae Volume 2

    • Authors : - (2020)

  • This book represents research papers based around metabolomics, to improve knowledge on the metabolome and metabolism in algae, with a focus on carbon and nitrogen resource allocation. It also describes many bioanalytical techniques and emphasizes their usefulness in microalgal biotechnology. Other aspects from an ecological, biotechnological and waste-water remediation perspective are also covered.
  • Ebooks (Sách điện tử)

  • Molecular Marker Technology for Crop Improvement

    • Authors : - (2020)

  • This Special Issue collects 16 research studies, including the application of molecular markers in 11 crop species, from the generation of linkage maps and diversity studies to the application of marker-assisted selection and genomic prediction.
  • Book

  • Byproducts, Waste Biomass and Products to form Green Diesel and Biocrude Oils

    • Authors : - (2020)

  • This book provides a collection of research and review articles useful for researchers, engineers, students and industry experts in the bioenergy field. The practical and valuable information can be utilized for developing and implementing renewable energy projects, selecting different waste feedstocks, technologies, and products. A detailed insight into advanced technologies such as hydrothermal liquefaction, torrefaction, and supercritical CO2 extraction for making sustainable ...
  • Journal article

  • Co-Occurrence of Enzyme Domains Guides the Discovery of an Oxazolone Synthetase

    • Authors : Rond, Tristan de; Asay, Julia E.; Moore, Bradley S. (2020)

  • The development of a new genome mining approach for the targeted discovery of novel biochemical transformations through the analysis of co-occurring enzyme domains (CO-ED) in a single protein. CO-ED was designed to identify unannotated multifunctional enzymes for functional characterization and discovery based on the premise that linked enzyme domains have evolved to function collaboratively. Guided by CO-ED, we targeted an unannotated predicted ThiF-nitroreductase di-domai...
  • Journal article

  • Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

    • Authors : Miyazaki, Ryoji; Akiyama, Yoshinori; Mori, Hiroyuki (2020)

  • To attempt at delineating the pathway of the VemP nascent-chain interaction with Sec-related factors, and identified the signal recognition particle (SRP) and PpiD (a membrane-anchored periplasmic chaperone) in addition to other translocon components and a ribosomal protein as interacting partners. Our results showed that SRP is required for the membrane-targeting of VemP, whereas PpiD acts cooperatively with SecD/F in the VemP arrest-cancelation. We also identifi...
  • Journal article

  • Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins

    • Authors : - (2020)

  • Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAMP effector proteins protein-kinase A and EPAC are found in complexes that also contain phosphodiesterases whose presence ensures a coordinated cellular response to receptor activation events. Popeye proteins are the most recent ...
  • Journal article

  • Suppression of amyloid-b secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

    • Authors : Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Saito, Haruka (2020)

  • C9,t11CLA significantly suppressed generation of Aβ in primary cultures of mouse neurons. CLA treatment did not affect the levels of β-site APP-cleaving enzyme 1 (BACE1), a component of active γ-secretase complex presenilin 1 amino-terminal fragment (PS1 NTF), or Aβ protein precursor (APP) in cultured neurons. BACE1 activity in lysate of neurons treated with c9,t11 CLA, but not t10,c12 CLA, decreased slightly, although c9,t11 CLA did not directly affect&...
  • Periodicals (Báo – Tạp chí)

  • The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

    • Authors : Eberle, Raphael J. (2020)

  • The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide resulting in a pandemic of unprecedented magnitude. To date, no clinically safe drug or vaccine is available and the development of molecules to combat SARS-CoV-2 infections is imminent. A well-known strategy to identify molecules with inhibitory potential against SARS-CoV-2 proteins is the repurposing of clinically developed drugs, e.g., anti-parasitic drugs. The results described in this study dem...
  • Journal article

  • Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

    • Authors : Mahootchi, Elaheh; Raasakka, Arne; Luan, Weisha (2020)

  • the crystal structure of mouse CSAD and compared it to other PLP-dependent decarboxylases in order to identify determinants of substrate specificity and catalytic activity. Recognition of the substrate involves distinct side chains forming the substrate-binding cavity. In addition, the backbone conformation of a buried active-site loop appears to be a critical determinant for substrate side chain binding in PLPdependent decarboxylases. phe94 was predicted to affect...