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  • Journal article

  • Single-particle view of stress-promoters induction dynamics: an interplay between MAPK signaling, chromatin and transcription factors

    • Authors : Bamberger, Casimir; Pankow, Sandra; Bartolomé, Salvador Martínez (2020)

  • Precise regulation of gene expression in response to environmental changes is crucial for cell survival, adaptation and proliferation. In eukaryotic cells, extracellular signal integration is often carried out by Mitogen-Activated Protein Kinases (MAPK). Despite a robust MAPK signaling activity, downstream gene expression can display a great variability between single cells. Using a live mRNA reporter, we monitored the dynamics of transcription in Saccharomyces cerevisiae&#...
  • Journal article

  • Covalent Protein Painting Reveals Structural Changes in the Proteome in Alzheimer Disease

    • Authors : Bamberger, Casimir; Pankow, Sandra; Bartolomé, Salvador Martínez (2020)

  • The 3D structures of aberrant protein folds have been visualized in exquisite detail, yet no method has been able to quantitatively measure protein misfolding across a proteome. Here, we present Covalent Protein Painting (CPP), a mass spectrometry-based structural proteomics approach to quantify the accessibility of lysine ε-amines for chemical modification at the surface of natively folded proteins. We used CPP to survey 2,645 lysine residues in the pro...