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  • Journal article

  • Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and function

    • Authors : Good, Nathan M; Fellner, Matthias; Demirer, Kemal (2020)

  • The presence of lanthanide elements (Ln3+) and pyrroloquinoline quinone (PQQ) containing cofactors in XoxF methanol dehydrogenases (MDHs) and ExaF ethanol dehydrogenases (EDHs) has expanded the list of biological elements and opened novel areas of metabolism and ecology. Other MDHs known as MxaFIs are related in sequence and structure to these proteins, yet they instead possess a Ca2+-PQQ cofactor. An important missing piece of the Ln3+ puzzle is definin...