Tìm kiếm nâng cao

Current filters:




Current filters:




Search Results

  • previous
  • 1
  • next
Item hits:
  • Journal article


  • Authors : Bignon, Emmanuelle; Claerbout, Victor; Jiang, Tao (2020)

  • Apurinic/apyrimidinic (AP) sites are the most common DNA lesions, which benefit from a most efficient repair by the base excision pathway. The impact of losing a nucleobase on the conformation and dynamics of B-DNA is well characterized. Yet AP sites seem to present an entirely different chemistry in nucleosomal DNA, with lifetimes reduced up to 100-fold, and the much increased formation of covalent DNA-protein cross-links, refractory to repair....