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  • Periodicals (Báo – Tạp chí)

  • Closing coronavirus spike glycoproteins by structure-guided design

    • Authors : McCallum, Matthew; Walls, Alexandra C; Corti, Davide (2020)

  • The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and host membranes. Although SARS-CoV- 2 S is the main target of neutralizing antibodies and the focus&...
  • Journal article

  • Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein

    • Authors : Walls, Alexandra C; Park, Young-Jun; Tortorici, M. Alejandra (2020)

  • The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main target of the humoral immune response. We show here that SARS-CoV-2 S mediates entry in VeroE6 cells and in BHK cells transiently transfected with human ACE2, establishing ACE2 ...