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  • Journal article

  • Membrane Insertion of Mycobacterium tuberculosis EsxA in Cultured Lung Epithelial Cells

    • Authors : Zhang, Qi; Aguilera, Javier (2020)

  • EsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb virulence. However, current data regarding to its role in Mtb virulence are controversial. Here, we have obtained evidence showing that the cytolytic activity of EsxA at neutral pH is due to contamination of ASB-14, a detergent used in EsxA preparation. Moreover, it is for the first time we have found ...
  • Journal article

  • Membrane Insertion of Mycobacterium tuberculosis EsxA in Cultured Lung Epithelial Cells

    • Authors : Zhang, Qi; Aguilera, Javier; Reyes, Salvador Vazquez (2020)

  • EsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb virulence. However, current data regarding to its role in Mtb virulence are controversial. Here, we have obtained evidence showing that the cytolytic activity of EsxA at neutral pH is due to contamination of ASB-14, a detergent used in EsxA preparation. Moreover, it is for the first time we have found ...
  • Journal article

  • Nα-acetylation of EsxA is required for mycobacterial cytosolic translocation and virulence

    • Authors : Aguilera, Javier; Karki, Chitra B; Li, Lin (2020)

  • Mycobacterium tuberculosis virulence factors, EsxA and EsxB, are secreted as a heterodimer (EsxA:B) and play an essential role in mycobacterial phagosomal escape and cytosolic translocation. Current studies support a model that EsxA must dissociate from its chaperon EsxB at low pH in order for EsxA to interact with host membranes. However, the mechanism of the heterodimer separation is not clear. In the present study, we have obtained evidence that&...