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  • Book

  • Antioxidant Activity of Polyphenolic Plant Extracts

    • Authors : - (2021)

  • This book brings together experts from different research fields on topics related to polyphenols, such as their isolation and purification, assessment of their antioxidant activity, prevention from oxidative stress-induced diseases and use as food additives. The polyphenols used in the present studies are derived from a great variety of plants, ranging from well-known species to rare ones that are only found in specific regions. Moreover, some of the&#x...
  • Book

  • Rice Improvement: Physiological, Molecular Breeding and Genetic Perspectives

    • Authors : - (2021)

  • This book emphasizes on the areas of rice science that attempt to overcome the foremost limitations in rice production. Our intention is to highlight research advances in the fields of physiology, molecular breeding and genetics, with a special focus on increasing productivity, improving biotic and abiotic stress tolerance and nutritional quality of rice. ; Up-to-date contributions by experts from international research centers and universities Provides practical&...
  • Journal article

  • Etmopterus lantern sharks use coelenterazine as the substrate for their luciferin-luciferase bioluminescence system

    • Authors : Mizuno, Gaku (2021)

  • The lantern shark genus Etmopterus is a group of deep-sea bioluminescent fishes. Theyemit blue light mainly from the ventral body surface, and the primary biological functionis considered to be for camouflage by counterillumination. In this study, we detected bothcoelenterazine and coelenterazine-specific luciferase activity in the ventral photophoretissues. The results suggested that bioluminescence in lantern sharks is produced usingcoelenterazine as the substrate for the ...
  • Periodicals (Báo – Tạp chí)

  • Structural properties and peptide ligand binding of the capsid homology domains of human Arc

    • Authors : Hallin1, Erik I.; Clive R., Bramham1; Kursula, Petri (2021)

  • The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic scaling and the normal function of the brain. Arc interacts with many neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully established. The C-terminal domain of Arc consists of tandem domains, termed the N- and C-lobe. The N-lobe harbours a peptide binding site, able to bind to multiple targets. By measuring the affinity of&#x...
  • Journal article

  • The P1 and P2 helices of the Guanidinium-II riboswitch interact in a ligand-dependent manner

    • Authors : Fuks, Christin (2021)

  • Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop interaction between the P1 and P2 hairpins. While an interaction was shown for isolated hairpins in crystallization and EPR experiments, an intrastrand kissing loop formation has not been demonstrated. Here, we report...
  • Journal article

  • Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD (14/96/109)

    • Authors : Perera, Luke A. (2021)

  • The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present long-sought crystallographic and solution structures of a deAMPylation Michaelis complex formed between mammalian AMPylated BiP and FICD. The latter, via its tetratricopeptide repeat domain, binds a surface that is specific&#x...