Journal articleAuthors : Fornasier, Emanuele (2021)
The SARS-CoV-2 main protease (Mpro) has a pivotal role in mediating viral genome replication and
transcription of coronavirus, making it a promising target for drugs against Covid-19 pandemic.
Here we present a crystal structure of Mpro disclosing new structural features of key regions of the
enzyme. We show that the oxyanion loop, involved in substrate recognition and enzymatic activity,
can adopt a new conformation, which is stable&#... 
