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  • Journal article

  • Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs

    • Authors : Almasy, Katherine M. (2021)

  • Human coronaviruses have become an increasing threat to global health; three highly pathogenic strains have emerged since the early 2000s, including most recently SARS-CoV-2, the cause of COVID-19. A better understanding of the molecular mechanisms of coronavirus pathogenesis is needed, including how these highly virulent strains differ from those that cause milder, common-cold like disease. While significant progress has been made in understanding how SARS-CoV-2 ...
  • Journal article

  • Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

    • Authors : Ragotte, Robert J. (2021)

  • Basigin, or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. Basigin also has a well-established role in Plasmodium falciparum malaria infection of human erythrocytes where it is bound by one of the parasite’s invasion ligands, reticulocyte binding protein homolog 5 (RH5). Here, we sought to validate the claim that the receptor binding domain (RBD) of SARS-CoV-2 spike glycoprotein can form a complex with basigi...