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  • Journal Article

  • Conformation and structural dynamics of the Xist lncRNA A-repeats

    • Authors : Jones, Alisha N. (2023)

  • Long noncoding RNAs (lncRNAs) are non‐protein‐encoding transcripts with lengths of 500 or more nucleotides (nt), with some spanning up to several thousands of nucleotides 1. LncRNAs have emerged as important regulators of gene expression and cellular functions, as transcriptional regulators at the level of chromatin, as scaffolding platforms, and as guides for RNP localization 2–9. Recent advancements in chemical probing experiments and their couplin...
  • Journal Article

  • Structure and function of a YeeE-YeeD complex for sophisticated thiosulfate uptake

    • Authors : Ikei, Mai (2023)

  • From bacteria to eukaryotes, sulfur is a vital element for cellular activities. For example, sulfur34 containing biomolecules, such as L-cysteine, L-methionine, thiamine, glutathione, and biotin, play a 35 variety of essential roles in cells (1). Bacteria and plants can utilize L-cysteine as a source of sulfate, 36 but they also have sulfur assimilation pathways to synthesize L-cysteine from inorganic sulfur 37 compounds. In bacteria, L-cysteine...