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  • Journal article

  • Structure of the human Bre1 complex bound to the nucleosome

    • Authors : Onishi, Shuhei  (2023)

  • Histone H2B monoubiquitination (at Lys120 in humans) regulates transcription elongation and DNA repair. In humans, H2B monoubiquitination is catalyzed by the heterodimeric Bre1 complex composed of Bre1A/RNF20 and Bre1B/RNF40. The Bre1 proteins generally function as tumor suppressors, while in certain cancers, they facilitate cancer cell proliferation. To reveal the structural basis of H2BK120 ubiquitination and its regulation, we determined the cryo-EM structure of...
  • Ebooks (Sách điện tử)

  • Structure of puromycin-sensitive aminopeptidase and polyglutamine binding

    • Authors : Madabushi, Sowmya (2023)

  • Puromycin-sensitive aminopeptidase (E.C. 3.4.11.14, UniProt P55786), a zinc 6 metallopeptidase belonging to the M1 family, degrades a number of bioactive peptides as 7 well as peptides released from the proteasome, including polyglutamine. We report the 8 crystal structure of PSA at 2.3 Ǻ. Overall, the enzyme adopts a V-shaped architecture 9 with four domains characteristic of the M1 family aminopeptidases, but it is in a less 10...