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  • Journal article


  • Authors : McCorvie, Thomas J. (2023)

  • Cystathionine beta-synthase (CBS) is an essential metabolic enzyme across all domains of life involved in the production of glutathione, cysteine, and hydrogen sulphide1-4. Human CBS appends to its conserved catalytic domain a regulatory domain that modulates activity by S-adenosyl-L-methionine (SAM) and promotes oligomerization5-12, however the molecular basis is unknown. Here we show using cryo-electron microscopy that full-length human CBS in the basa...